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Published in 2022 at "ACS chemical biology"
DOI: 10.1021/acschembio.2c00717
Abstract: Primase-DNA polymerase (PrimPol) is involved in reinitiating DNA synthesis at stalled replication forks. PrimPol also possesses DNA translesion (TLS) activity and bypasses several endogenous nonbulky DNA lesions in vitro. Little is known about the TLS…
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Keywords:
dna;
primpol;
translesion;
synthesis ... See more keywords
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1
Published in 2022 at "Nature Communications"
DOI: 10.1038/s41467-021-27872-7
Abstract: Defects in BRCA1 , BRCA2 and other genes of the homology-dependent DNA repair (HR) pathway cause an elevated rate of mutagenesis, eliciting specific mutation patterns including COSMIC signature SBS3. Using genome sequencing of knock-out cell…
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Keywords:
mutagenesis;
base;
synthesis;
brca1 ... See more keywords
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1
Published in 2022 at "eLife"
DOI: 10.1101/2022.08.14.503212
Abstract: Translesion synthesis mediated by translesion polymerases is a conserved mechanism of DNA damage tolerance. In bacteria, DinB enzymes are widely distributed promutagenic translesion polymerases. The role of DinBs in mycobacterial mutagenesis was unclear until recent…
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Keywords:
frameshift;
substitution;
translesion;
dinb2 ... See more keywords
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0
Published in 2020 at "Journal of Clinical Pathology"
DOI: 10.1136/jclinpath-2020-207131
Abstract: Aims DNA methylation has its distribution influenced by DNA demethylation processes with the catalytic conversion of 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC). Myelodysplastic syndrome (MDS) has been associated with epigenetic dysregulation of genes related to DNA…
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Keywords:
methylation;
irf;
dna;
translesion ... See more keywords
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1
Published in 2022 at "Genes"
DOI: 10.3390/genes13020166
Abstract: DNA-protein cross-links (DPCs) are extremely bulky adducts that interfere with replication. In human cells, they are processed by SPRTN, a protease activated by DNA polymerases stuck at DPCs. We have recently proposed the mechanism of…
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Keywords:
dna;
translesion;
cross;
dna polymerases ... See more keywords
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0
Published in 2017 at "eLife"
DOI: 10.7554/elife.32177
Abstract: High fidelity replicative DNA polymerases are unable to synthesize past DNA adducts that result from diverse chemicals, reactive oxygen species or UV light. To bypass these replication blocks, cells utilize specialized translesion DNA polymerases that…
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Keywords:
single molecule;
dna;
translesion;
translesion polymerases ... See more keywords