Translesion Synthesis across the N2-Ethyl-deoxyguanosine Adduct by Human PrimPol.
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DOI: 10.1021/acschembio.2c00717
Abstract: Primase-DNA polymerase (PrimPol) is involved in reinitiating DNA synthesis at stalled replication forks. PrimPol also possesses DNA translesion (TLS) activity and bypasses several endogenous nonbulky DNA lesions in vitro. Little is known about the TLS… read more here.
Keywords: dna; primpol; translesion; synthesis ... See more keywords
BRCA1 deficiency specific base substitution mutagenesis is dependent on translesion synthesis and regulated by 53BP1
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DOI: 10.1038/s41467-021-27872-7
Abstract: Defects in BRCA1 , BRCA2 and other genes of the homology-dependent DNA repair (HR) pathway cause an elevated rate of mutagenesis, eliciting specific mutation patterns including COSMIC signature SBS3. Using genome sequencing of knock-out cell… read more here.
Keywords: mutagenesis; base; synthesis; brca1 ... See more keywords
Roles for mycobacterial DinB2 in frameshift and substitution mutagenesis
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DOI: 10.1101/2022.08.14.503212
Abstract: Translesion synthesis mediated by translesion polymerases is a conserved mechanism of DNA damage tolerance. In bacteria, DinB enzymes are widely distributed promutagenic translesion polymerases. The role of DinBs in mycobacterial mutagenesis was unclear until recent… read more here.
Keywords: frameshift; substitution; translesion; dinb2 ... See more keywords
Tissue methylation and demethylation influence translesion synthesis DNA polymerases (TLS) contributing to the genesis of chromosomal abnormalities in myelodysplastic syndrome
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DOI: 10.1136/jclinpath-2020-207131
Abstract: Aims DNA methylation has its distribution influenced by DNA demethylation processes with the catalytic conversion of 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC). Myelodysplastic syndrome (MDS) has been associated with epigenetic dysregulation of genes related to DNA… read more here.
Keywords: methylation; irf; dna; translesion ... See more keywords
Stalling of Eukaryotic Translesion DNA Polymerases at DNA-Protein Cross-Links
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DOI: 10.3390/genes13020166
Abstract: DNA-protein cross-links (DPCs) are extremely bulky adducts that interfere with replication. In human cells, they are processed by SPRTN, a protease activated by DNA polymerases stuck at DPCs. We have recently proposed the mechanism of… read more here.
Keywords: dna; translesion; cross; dna polymerases ... See more keywords
Single-molecule studies contrast ordered DNA replication with stochastic translesion synthesis
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DOI: 10.7554/elife.32177
Abstract: High fidelity replicative DNA polymerases are unable to synthesize past DNA adducts that result from diverse chemicals, reactive oxygen species or UV light. To bypass these replication blocks, cells utilize specialized translesion DNA polymerases that… read more here.
Keywords: single molecule; dna; translesion; translesion polymerases ... See more keywords