Artificial Nucleosides as Diagnostic Probes to Measure Translesion DNA Synthesis.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9216-4_15
Abstract: The misreplication of damaged DNA, a biological process termed translesion DNA synthesis (TLS), produces a large number of adverse effects on human health. This chapter describes the application of an artificial nucleoside/nucleotide system that functions… read more here.
Keywords: translesion dna; dna synthesis; chemistry; dna ... See more keywords
Sgs1 helicase is required for efficient PCNA monoubiquitination and translesion DNA synthesis in Saccharomyces cerevisiae
Sign Up to like & getrecommendations! Published in 2017 at "Current Genetics"
DOI: 10.1007/s00294-017-0753-0
Abstract: DNA-damage tolerance (DDT) is employed by eukaryotes to deal with replication blocks on the template strand, and is divided into two parallel pathways that are activated by sequential ubiquitination of proliferating cell nuclear antigen (PCNA)… read more here.
Keywords: dna synthesis; pcna monoubiquitination; dna; sgs1 ... See more keywords
Engineering of the Translesion DNA Synthesis Pathway Enables Controllable C-to-G and C-to-A Base Editing in Corynebacterium glutamicum.
Sign Up to like & getrecommendations! Published in 2022 at "ACS synthetic biology"
DOI: 10.1021/acssynbio.2c00265
Abstract: Expanding the base conversion type is expected to largely broaden the application of base editing, whereas it requires decipherment of the machinery controlling the editing outcome. Here, we discovered that the DNA polymerase V-mediated translesion… read more here.
Keywords: corynebacterium glutamicum; translesion dna; dna synthesis; base editing ... See more keywords
Translesion DNA polymerases in eukaryotes: what makes them tick?
Sign Up to like & getrecommendations! Published in 2017 at "Critical Reviews in Biochemistry and Molecular Biology"
DOI: 10.1080/10409238.2017.1291576
Abstract: Abstract Life as we know it, simply would not exist without DNA replication. All living organisms utilize a complex machinery to duplicate their genomes and the central role in this machinery belongs to replicative DNA… read more here.
Keywords: dna; eukaryotes makes; dna polymerases; polymerases eukaryotes ... See more keywords
Characterisation of the spectrum and genetic dependence of collateral mutations induced by translesion DNA synthesis
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Genetics"
DOI: 10.1371/journal.pgen.1010051
Abstract: Translesion DNA synthesis (TLS) is a fundamental damage bypass pathway that utilises specialised polymerases with relaxed template specificity to achieve replication through damaged DNA. Misinsertions by low fidelity TLS polymerases may introduce additional mutations on… read more here.
Keywords: translesion dna; collateral; collateral mutations; dna synthesis ... See more keywords