Total Synthesis of (−)-Lepadiformine A viaRadical Translocation–Cyclization Reaction
Sign Up to like & getrecommendations! Published in 2020 at "Organic Letters"
DOI: 10.1021/acs.orglett.0c00474.s001
Abstract: Total synthesis of (−)-lepadiformine A featuring construction of the 1-azaspiro[4.5]decane skeleton by a highly diastereoselective radical translocation–cyclization reaction of a γ-lactam derivative bearing a chiral butenolide moiety is described. The enantioselective construction of butenolide is… read more here.
Keywords: translocation cyclization; total synthesis; cyclization reaction;
Visible-light photocatalytic radical addition-translocation-cyclization to construct sulfonyl-containing azacycles.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d2cc03799h
Abstract: Herein, a novel visible-light photocatalytic radical addition-translocation-cyclization (RATC) approach for the efficient synthesis of sulfonyl-containing azacycles is described. The reaction delivers a wide range of monocyclic, bicyclic and polycyclic azacycles by using easily prepared sodium… read more here.
Keywords: translocation cyclization; addition translocation; photocatalytic radical; radical addition ... See more keywords