Computational analysis of pathological images enables a better diagnosis of TFE3 Xp11.2 translocation renal cell carcinoma
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DOI: 10.1038/s41467-020-15671-5
Abstract: TFE3 Xp11.2 translocation renal cell carcinoma (TFE3-RCC) generally progresses more aggressively compared with other RCC subtypes, but it is challenging to diagnose TFE3-RCC by traditional visual inspection of pathological images. In this study, we collect… read more here.
Keywords: renal cell; tfe3; tfe3 rcc; translocation renal ... See more keywords
PD-L1 expression in Xp11.2 translocation renal cell carcinoma: Indicator of tumor aggressiveness
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DOI: 10.1038/s41598-017-02005-7
Abstract: Programmed death ligand-1 (PD-L1), a promising antitumor target, has proven clinical value against many malignancies. However, the PD-L1 content of Xp11.2 translocation renal cell carcinoma (Xp11.2 RCC) and its correlation with clinical outcomes remain unclear.… read more here.
Keywords: xp11 translocation; xp11 rcc; expression; translocation renal ... See more keywords
Metastatic adult Xp11.2 translocation renal cell carcinoma with TFE3 gene fusion in complete remission
Sign Up to like & getrecommendations! Published in 2020 at "Baylor University Medical Center Proceedings"
DOI: 10.1080/08998280.2020.1847946
Abstract: Abstract Xp11 translocation renal cell carcinoma (RCC) accounts for most pediatric cases of RCC but is uncommon in adults. It has an aggressive course in adults with poor response to chemoradiation. We describe a 64-year-old… read more here.
Keywords: xp11 translocation; renal cell; complete remission; cell carcinoma ... See more keywords
Therapeutic Targeting of TFE3/IRS-1/PI3K/mTOR Axis in Translocation Renal Cell Carcinoma
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DOI: 10.1158/1078-0432.ccr-18-0269
Abstract: Purpose: Translocation renal cell carcinoma (tRCC) represents a rare subtype of kidney cancer associated with various TFE3, TFEB, or MITF gene fusions that are not responsive to standard treatments for RCC. Therefore, the identification of… read more here.
Keywords: pi3k; trcc; mtor; translocation renal ... See more keywords
Abstract 4495: A mechanistic study of the TFE3-splicing machinery gene fusions reveals a new druggable target for translocation renal cell carcinoma
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-4495
Abstract: TFE3 is a member of basic helix-loop-helix leucine zipper MiT transcription factor family and its chimeric proteins are associated with translocation renal cell carcinoma (tRCC). Despite the variety of genes fusions, most of TFE3 fusions… read more here.
Keywords: cell; cell carcinoma; renal cell; machinery ... See more keywords
Efficacy of cabozantinib in advanced MiT family translocation renal cell carcinomas (TRCC).
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2021.39.6_suppl.274
Abstract: 274Background: MiT family translocation renal cell carcinomas (TRCC) represent a rare and aggressive subgroup of RCC harboring high expression of c-MET. While response rates of VEGF receptor-tyrosi... read more here.
Keywords: renal cell; mit family; family translocation; translocation renal ... See more keywords
ASO Author Reflections: The Oncologic Efficacy and Feasibility of Nephron-Sparing Surgery for Adult Xp11.2 Translocation Renal Cell Carcinoma
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DOI: 10.1245/s10434-020-08814-x
Abstract: Since the description of Xp11.2 translocation renal cell carcinoma as a clinicopathologic entity in 2001, it has attracted increasing attention. This study focused on the oncologic efficacy and feasibility of nephron-sparing surgery (NSS) in this… read more here.
Keywords: xp11 translocation; renal cell; carcinoma; translocation renal ... See more keywords
Gene Expression Analysis of Aggressive Adult Xp11.2 Translocation Renal Cell Carcinoma at Clinical Stage T1N0M0 to Identify Potential Prognostic and Therapeutic Biomarkers
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DOI: 10.3390/biomedicines10020321
Abstract: Xp11.2 translocation renal cell carcinoma (tRCC), involving transcription factor E3 (TFE3) gene fusions, is a rare and aggressive RCC variant when present in adults and has been recently recognized as a unique entity in RCC.… read more here.
Keywords: cell; xp11; trcc; xp11 trcc ... See more keywords
MiTF/TFE Translocation Renal Cell Carcinomas: From Clinical Entities to Molecular Insights
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23147649
Abstract: MiTF/TFE translocation renal cell carcinoma (tRCC) is a rare and aggressive subtype of RCC representing the most prevalent RCC in the pediatric population (up to 40%) and making up 4% of all RCCs in adults.… read more here.
Keywords: renal cell; mitf tfe; trcc; tfe translocation ... See more keywords