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   Articles with "translocon" as a keyword



Characterization of the interaction between the Sec61 translocon complex and ppαF using optical tweezers

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recommendations! Published in 2024 at "Protein Science"

DOI: 10.1002/pro.4996

Abstract: The Sec61 translocon allows the translocation of secretory preproteins from the cytosol to the endoplasmic reticulum lumen during polypeptide biosynthesis. These proteins possess an N‐terminal signal peptide (SP) which docks at the translocon. SP mutations… read more here.

Keywords: characterization interaction; optical tweezers; sec61 translocon; translocon ... See more keywords

Malaria Parasite Translocon Structure and Mechanism of Effector Export

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recommendations! Published in 2018 at "Nature"

DOI: 10.1038/s41586-018-0469-4

Abstract: The putative Plasmodium translocon of exported proteins (PTEX) is essential for transport of malarial effector proteins across a parasite-encasing vacuolar membrane into host erythrocytes, but the mechanism of this process remains unknown. Here we show… read more here.

Keywords: mechanism; microscopy; effector export; effector ... See more keywords

Structural determinants of a permeation barrier of the SecYEG translocon in the active state

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recommendations! Published in 2021 at "Physical Chemistry Chemical Physics"

DOI: 10.1039/d1cp02702f

Abstract: The SecYEG translocon is a channel in bacteria, which provides a passage for secretory proteins across as well as integration of membrane proteins into the plasma membrane. The molecular mechanism, by which SecYEG manages protein… read more here.

Keywords: structural determinants; translocon active; active state; secyeg translocon ... See more keywords

Evidence for a Widespread Third System for Bacterial Polysaccharide Export across the Outer Membrane Comprising a Composite OPX/β-Barrel Translocon

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recommendations! Published in 2022 at "mBio"

DOI: 10.1128/mbio.02032-22

Abstract: Bacteria secrete a wide variety of polysaccharides that have critical functions in, e.g., fitness, surface colonization, and biofilm formation and in beneficial and pathogenic human-, animal-, and plant-microbe interactions. In Gram-negative bacteria, export of these… read more here.

Keywords: outer membrane; translocon; barrel; biology ... See more keywords

Sec translocon has an insertase-like function in addition to polypeptide conduction through the channel

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recommendations! Published in 2019 at "F1000Research"

DOI: 10.12688/f1000research.21065.1

Abstract: The Sec translocon provides a polypeptide-conducting channel, which is insulated from the hydrophobic lipidic environment of the membrane, for translocation of hydrophilic passenger polypeptides. Its lateral gate allows a downstream hydrophobic segment (stop-transfer sequence) to… read more here.

Keywords: novo insertion; channel; function; translocon ... See more keywords
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The type 3 secretion system requires actin polymerization to open translocon pores

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recommendations! Published in 2021 at "PLoS Pathogens"

DOI: 10.1371/journal.ppat.1009932

Abstract: Many bacterial pathogens require a type 3 secretion system (T3SS) to establish a niche. Host contact activates bacterial T3SS assembly of a translocon pore in the host plasma membrane. Following pore formation, the T3SS docks… read more here.

Keywords: polymerization; secretion system; actin polymerization; type secretion ... See more keywords

Sec61 complex/translocon: The role of an atypical ER Ca2+-leak channel in health and disease

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recommendations! Published in 2022 at "Frontiers in Physiology"

DOI: 10.3389/fphys.2022.991149

Abstract: The heterotrimeric Sec61 protein complex forms the functional core of the so-called translocon that forms an aqueous channel in the endoplasmic reticulum (ER). The primary role of the Sec61 complex is to allow protein import… read more here.

Keywords: ca2 leak; translocon; sec61; sec61 complex ... See more keywords

Reconstitution of surface lipoprotein translocation through the Slam translocon

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recommendations! Published in 2022 at "eLife"

DOI: 10.7554/elife.72822

Abstract: Surface lipoproteins (SLPs) are peripherally attached to the outer leaflet of the outer membrane in many Gram-negative bacteria, playing significant roles in nutrient acquisition and immune evasion in the host. While the factors that are… read more here.

Keywords: reconstitution surface; translocation; outer membrane; surface ... See more keywords