Malaria Parasite Translocon Structure and Mechanism of Effector Export
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DOI: 10.1038/s41586-018-0469-4
Abstract: The putative Plasmodium translocon of exported proteins (PTEX) is essential for transport of malarial effector proteins across a parasite-encasing vacuolar membrane into host erythrocytes, but the mechanism of this process remains unknown. Here we show… read more here.
Keywords: mechanism; microscopy; effector export; effector ... See more keywords
Structural determinants of a permeation barrier of the SecYEG translocon in the active state
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DOI: 10.1039/d1cp02702f
Abstract: The SecYEG translocon is a channel in bacteria, which provides a passage for secretory proteins across as well as integration of membrane proteins into the plasma membrane. The molecular mechanism, by which SecYEG manages protein… read more here.
Keywords: structural determinants; translocon active; active state; secyeg translocon ... See more keywords
Evidence for a Widespread Third System for Bacterial Polysaccharide Export across the Outer Membrane Comprising a Composite OPX/β-Barrel Translocon
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DOI: 10.1128/mbio.02032-22
Abstract: Bacteria secrete a wide variety of polysaccharides that have critical functions in, e.g., fitness, surface colonization, and biofilm formation and in beneficial and pathogenic human-, animal-, and plant-microbe interactions. In Gram-negative bacteria, export of these… read more here.
Keywords: outer membrane; translocon; barrel; biology ... See more keywords
Sec translocon has an insertase-like function in addition to polypeptide conduction through the channel
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DOI: 10.12688/f1000research.21065.1
Abstract: The Sec translocon provides a polypeptide-conducting channel, which is insulated from the hydrophobic lipidic environment of the membrane, for translocation of hydrophilic passenger polypeptides. Its lateral gate allows a downstream hydrophobic segment (stop-transfer sequence) to… read more here.
Keywords: novo insertion; channel; function; translocon ... See more keywords
The type 3 secretion system requires actin polymerization to open translocon pores
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DOI: 10.1371/journal.ppat.1009932
Abstract: Many bacterial pathogens require a type 3 secretion system (T3SS) to establish a niche. Host contact activates bacterial T3SS assembly of a translocon pore in the host plasma membrane. Following pore formation, the T3SS docks… read more here.
Keywords: polymerization; secretion system; actin polymerization; type secretion ... See more keywords
Sec61 complex/translocon: The role of an atypical ER Ca2+-leak channel in health and disease
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DOI: 10.3389/fphys.2022.991149
Abstract: The heterotrimeric Sec61 protein complex forms the functional core of the so-called translocon that forms an aqueous channel in the endoplasmic reticulum (ER). The primary role of the Sec61 complex is to allow protein import… read more here.
Keywords: ca2 leak; translocon; sec61; sec61 complex ... See more keywords
Reconstitution of surface lipoprotein translocation through the Slam translocon
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DOI: 10.7554/elife.72822
Abstract: Surface lipoproteins (SLPs) are peripherally attached to the outer leaflet of the outer membrane in many Gram-negative bacteria, playing significant roles in nutrient acquisition and immune evasion in the host. While the factors that are… read more here.
Keywords: reconstitution surface; translocation; outer membrane; surface ... See more keywords