In vitro assembly of Haemophilus influenzae adhesin transmembrane domain and studies on the electrostatic repulsion at the interface
Sign Up to like & getrecommendations! Published in 2019 at "Biophysical Reviews"
DOI: 10.1007/s12551-019-00535-0
Abstract: Haemophilus influenzae adhesin (Hia) belongs to the trimeric autotransporter family, and it mediates the adherence of these bacteria to the epithelial cells of host organisms. Hia is composed of the passenger domain, which is a… read more here.
Keywords: haemophilus influenzae; transmembrane domain; influenzae adhesin; electrostatic repulsion ... See more keywords
Transmembrane domain dependent inhibitory function of FcγRIIB
Sign Up to like & getrecommendations! Published in 2018 at "Protein & Cell"
DOI: 10.1007/s13238-018-0509-8
Abstract: FcγRIIB, the only inhibitory IgG Fc receptor, functions to suppress the hyper-activation of immune cells. Numerous studies have illustrated its inhibitory function through the ITIM motif in the cytoplasmic tail of FcγRIIB. However, later studies… read more here.
Keywords: inhibitory function; transmembrane domain; riib; function riib ... See more keywords
Mapping pathogenic mutations suggests an innovative structural model for the pendrin (SLC26A4) transmembrane domain.
Sign Up to like & getrecommendations! Published in 2017 at "Biochimie"
DOI: 10.1016/j.biochi.2016.10.002
Abstract: Human pendrin (SLC26A4) is an anion transporter mostly expressed in the inner ear, thyroid and kidney. SLC26A4 gene mutations are associated with a broad phenotypic spectrum, including Pendred Syndrome and non-syndromic hearing loss with enlarged… read more here.
Keywords: transmembrane; transmembrane domain; model; pendrin slc26a4 ... See more keywords
The oligomerization mediated by the alanine 397 residue in the transmembrane domain is crucial to sydecan-3 functions.
Sign Up to like & getrecommendations! Published in 2020 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2020.109544
Abstract: Syndecans are single-pass transmembrane proteins on the cell surface that are involved in various cellular functions. Previously, we reported that both homo- and hetero-form of syndecan dimers affected their functionality. However, little is known about… read more here.
Keywords: transmembrane; alanine 397; transmembrane domain; oligomer formation ... See more keywords
Ligand-independent oligomerization of TACI is controlled by the transmembrane domain and regulates proliferation of activated B cells.
Sign Up to like & getrecommendations! Published in 2022 at "Cell reports"
DOI: 10.1016/j.celrep.2022.110583
Abstract: In mature B cells, TACI controls class-switch recombination and differentiation into plasma cells during T cell-independent antibody responses. TACI binds the ligands BAFF and APRIL. Approximately 10% of patients with common variable immunodeficiency (CVID) carry TACI… read more here.
Keywords: activated cells; ligand independent; taci; transmembrane domain ... See more keywords
The T Cell Antigen Receptor &agr; Transmembrane Domain Coordinates Triggering through Regulation of Bilayer Immersion and CD3 Subunit Associations
Sign Up to like & getrecommendations! Published in 2018 at "Immunity"
DOI: 10.1016/j.immuni.2018.09.007
Abstract: &NA; Initial molecular details of cellular activation following &agr;&bgr;T cell antigen receptor (TCR) ligation by peptide‐major histocompatibility complexes (pMHC) remain unexplored. We determined the nuclear magnetic resonance (NMR) structure of the TCR&agr; subunit transmembrane (TM)… read more here.
Keywords: cd3; transmembrane domain; tcr agr; tcr ... See more keywords
Structural characterization of a dimerization interface in the CD28 transmembrane domain.
Sign Up to like & getrecommendations! Published in 2022 at "Structure"
DOI: 10.1016/j.str.2022.03.004
Abstract: CD28 has a crucial role in regulating immune responses by enhancing T cell activation and differentiation. Recent studies have shown that the transmembrane helix (TMH) of CD28 mediates receptor assembly and activity, but a structural characterization… read more here.
Keywords: structural characterization; cd28; dimerization interface; tmh ... See more keywords
H7 virus-like particles assembled by hemagglutinin containing H3N2 transmembrane domain and M1 induce broad homologous and heterologous protection in mice
Sign Up to like & getrecommendations! Published in 2018 at "Vaccine"
DOI: 10.1016/j.vaccine.2018.07.004
Abstract: Abstract Influenza A H7N9 virus has caused five outbreak waves of human infections in China since 2013 and posed a dual challenge to public health and poultry industry. There is an urgent need to develop… read more here.
Keywords: virus like; transmembrane domain; hemagglutinin; like particles ... See more keywords
The melanocortin-2 receptor of the rainbow trout: Identifying a role for critical positions in transmembrane domain 4, extracellular loop 2, and transmembrane domain 5 in the activation of rainbow trout MC2R.
Sign Up to like & getrecommendations! Published in 2018 at "General and comparative endocrinology"
DOI: 10.1016/j.ygcen.2017.05.003
Abstract: The activation of either teleost or tetrapod melanocortin-2 receptor (MC2R) orthologs requires interaction between the HFRW motif and R/KKRRP motif in the primary sequence of ACTH, and two corresponding sites on the melanocortin 2 receptor.… read more here.
Keywords: melanocortin receptor; rainbow trout; transmembrane domain; activation ... See more keywords
The Importance of Val386 in Transmembrane Domain 8 for the Activation of OATP1B3 by Epigallocatechin Gallate.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c02692
Abstract: Estrone-3-sulfate (E3S) uptake mediated by organic anion transporting polypeptide 1B3 (OATP1B3) can be activated by epigallocatechin gallate (EGCG). In this study, by using chimeric transporters and site-directed mutagenesis, we found that Val386 in transmembrane domain… read more here.
Keywords: transmembrane domain; egcg; epigallocatechin gallate; activation oatp1b3 ... See more keywords
Structures of full-length glycoprotein hormone receptor signalling complexes.
Sign Up to like & getrecommendations! Published in 2021 at "Nature"
DOI: 10.1038/s41586-021-03924-2
Abstract: Luteinizing hormone and chorionic gonadotropin are glycoprotein hormones that are related to follicle-stimulating hormone and thyroid-stimulating hormone1,2. Luteinizing hormone and chorionic gonadotropin are essential to human reproduction and are important therapeutic drugs3-6. They activate the… read more here.
Keywords: receptor; hormone; transmembrane domain; glycoprotein hormone ... See more keywords