Effect of Phosphorylation on Interactions between Transmembrane Domains of SERCA and Phospholamban.
Sign Up to like & getrecommendations! Published in 2018 at "Biophysical journal"
DOI: 10.1016/j.bpj.2018.04.035
Abstract: We have used site-directed spin labeling and electron paramagnetic resonance (EPR) to map interactions between the transmembrane (TM) domains of the sarcoplasmic reticulum Ca2+-ATPase (SERCA) and phospholamban (PLB) as affected by PLB phosphorylation. In the… read more here.
Keywords: plb; interactions transmembrane; serca phospholamban; transmembrane domains ... See more keywords
Gly45 and Phe555 in Transmembrane Domains 1 and 10 are Critical for the Activation of OATP1B3 by Epigallocatechin Gallate.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.9b03812
Abstract: Organic anion transporting polypeptides (OATPs) 1B1 and 1B3 are two highly homologous transporters expressed in the human liver. However, epigallocatechin gallate (EGCG) which is the most predominant catechin in green tea has opposite effects on… read more here.
Keywords: transmembrane domains; activation oatp1b3; activation; epigallocatechin gallate ... See more keywords
Improving the secretion of designed protein assemblies through negative design of cryptic transmembrane domains
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2214556120
Abstract: Computationally designed protein nanoparticles have recently emerged as a promising platform for the development of new vaccines and biologics. For many applications, secretion of designed nanoparticles from eukaryotic cells would be advantageous, but in practice… read more here.
Keywords: cryptic transmembrane; secretion; design; designed protein ... See more keywords
Transmembrane domains of type III-secreted proteins affect bacterial-host interactions in enteropathogenic E. coli
Sign Up to like & getrecommendations! Published in 2021 at "Virulence"
DOI: 10.1080/21505594.2021.1898777
Abstract: ABSTRACT Many bacterial pathogens utilize a specialized secretion system, termed type III secretion system (T3SS), to translocate effector proteins into host cells and establish bacterial infection. The T3SS is anchored within the bacterial membranes and… read more here.
Keywords: host; transmembrane domains; membrane; type iii ... See more keywords
Intergenic Regions of Saccharomycotina Yeasts are Enriched in Potential to Encode Transmembrane Domains
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Biology and Evolution"
DOI: 10.1093/molbev/msad059
Abstract: Intergenic genomic regions have essential regulatory and structural roles that impose constraints on their sequences. But regions that do not currently encode proteins, also carry the potential to do so in the future. De novo… read more here.
Keywords: regions saccharomycotina; forming potential; intergenic regions; transmembrane domains ... See more keywords
Host Factor SPCS1 Regulates the Replication of Japanese Encephalitis Virus through Interactions with Transmembrane Domains of NS2B
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Virology"
DOI: 10.1128/jvi.00197-18
Abstract: ABSTRACT Signal peptidase complex subunit 1 (SPCS1) is a newly identified host factor that regulates flavivirus replication, but the molecular mechanism is not fully understood. Here, using Japanese encephalitis virus (JEV) as a model, we… read more here.
Keywords: protein; spcs1; host; transmembrane domains ... See more keywords
Deciphering the Potential Coding of Human Cytomegalovirus: New Predicted Transmembrane Proteome
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23052768
Abstract: CMV is a major cause of morbidity and mortality in immunocompromised individuals that will benefit from the availability of a vaccine. Despite the efforts made during the last decade, no CMV vaccine is available. An… read more here.
Keywords: transmembrane domains; transmembrane; coding human; deciphering potential ... See more keywords
Rotational Dynamics of The Transmembrane Domains Play an Important Role in Peptide Dynamics of Viral Fusion and Ion Channel Forming Proteins—A Molecular Dynamics Simulation Study
Sign Up to like & getrecommendations! Published in 2022 at "Viruses"
DOI: 10.3390/v14040699
Abstract: Focusing on the transmembrane domains (TMDs) of viral fusion and channel-forming proteins (VCPs), experimentally available and newly generated peptides in an ideal conformation of the S and E proteins of severe acute respiratory syndrome coronavirus… read more here.
Keywords: channel; fusion; forming proteins; viral fusion ... See more keywords
De novo-designed transmembrane domains tune engineered receptor functions
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.7554/elife.75660
Abstract: De novo-designed receptor transmembrane domains (TMDs) present opportunities for precise control of cellular receptor functions. We developed a de novo design strategy for generating programmed membrane proteins (proMPs): single-pass α-helical TMDs that self-assemble through computationally… read more here.
Keywords: receptor functions; novo designed; receptor; transmembrane domains ... See more keywords