Unravelling high-affinity binding compounds towards transmembrane protease serine 2 enzyme in treating SARS-CoV-2 infection using molecular modelling and docking studies
Sign Up to like & getrecommendations! Published in 2020 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2020.173688
Abstract: The coronavirus disease-19 (COVID-19) outbreak that is caused by a highly contagious severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has become a zoonotic pandemic, with approximately 24.5 million positive cases and 8.3 lakhs deaths globally. The… read more here.
Keywords: protease serine; transmembrane protease; high affinity; docking studies ... See more keywords
Angiotensin‐converting enzyme 2 and transmembrane protease serine 2 in female and male patients with end‐stage kidney disease
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Clinical Investigation"
DOI: 10.1111/eci.13786
Abstract: Individuals with chronic kidney disease are affected by acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) due to multiple comorbidities and altered immune system. The first step of the infection process is the binding of SARS‐CoV‐2 with… read more here.
Keywords: converting enzyme; kidney; transmembrane protease; kidney disease ... See more keywords
Upregulation of the transmembrane protease serine 3 mRNA level in radioresistant colorectal cancer tissues.
Sign Up to like & getrecommendations! Published in 2022 at "Biomarkers in medicine"
DOI: 10.2217/bmm-2021-0649
Abstract: Aim: To investigate the clinical role of transmembrane protease serine 3 (TMPRSS3) in radioresistance and prognosis of colorectal cancer (CRC). Methods: Standardized mean difference (SMD) and summary area under the curve (AUC) of TMPRSS3 were… read more here.
Keywords: crc; tmprss3; transmembrane protease; colorectal cancer ... See more keywords
The Transmembrane Protease TMPRSS2 as a Therapeutic Target for COVID-19 Treatment
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23031351
Abstract: TMPRSS2 is a type II transmembrane protease with broad expression in epithelial cells of the respiratory and gastrointestinal tract, the prostate, and other organs. Although the physiological role of TMPRSS2 remains largely elusive, several endogenous… read more here.
Keywords: tmprss2; transmembrane protease; covid treatment;