A Transmembrane Protein WAI-B2 Confers Multiple Disease Resistance in Wheat by Activating Autoimmunity.
Sign Up to like & getrecommendations! Published in 2025 at "Advanced science"
DOI: 10.1002/advs.202511576
Abstract: Wheat (Triticum aestivum L.) is one of the world's most important food crops and its production is frequently threatened by diseases caused by several biotrophic pathogens, including stripe rust, leaf rust, stem rust and powdery… read more here.
Keywords: resistance; wheat; autoimmunity; transmembrane protein ... See more keywords
Transmembrane protein 119 is neither a specific nor a reliable marker for microglia
Sign Up to like & getrecommendations! Published in 2022 at "Glia"
DOI: 10.1002/glia.24164
Abstract: Microglia are the resident innate immune cells of the central nervous system (CNS) parenchyma. To determine the impact of microglia on disease development and progression in neurodegenerative and neuroinflammatory diseases, it is essential to distinguish… read more here.
Keywords: neither specific; marker; tmem119; protein 119 ... See more keywords
Proline‐rich transmembrane protein 2 specifically binds to GluA1 but has no effect on AMPA receptor‐mediated synaptic transmission
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.24196
Abstract: Proline‐rich transmembrane protein 2 (PRRT2) is a neuron‐specific protein associated with seizures, dyskinesia, and intelligence deficit. Previous studies indicate that PRRT2 regulates neurotransmitter release from presynaptic membranes. However, PRRT2 can also bind AMPA‐type glutamate receptors… read more here.
Keywords: transmembrane protein; proline rich; rich transmembrane; protein ... See more keywords
Teneurin transmembrane protein 4 is not a cause for essential tremor in a Canadian population
Sign Up to like & getrecommendations! Published in 2017 at "Movement Disorders"
DOI: 10.1002/mds.26753
Abstract: Mutations in teneurin transmembrane protein 4 were reported to be a risk factor for essential tremor, but the relevance of this across different population remains to be examined. The aim of this study was to… read more here.
Keywords: teneurin transmembrane; transmembrane protein; essential tremor;
Proline‐rich transmembrane protein 2 regulates the magnitude and frequency of dopamine release by repetitive neuronal stimuli in the striatum of L‐dopa‐treated mice
Sign Up to like & getrecommendations! Published in 2024 at "Neuropsychopharmacology Reports"
DOI: 10.1002/npr2.12478
Abstract: Mutations in proline‐rich transmembrane protein 2 (PRRT2) cause paroxysmal kinesigenic dyskinesia (PKD). Recently, we reported that a Prrt2 mutation exacerbated L‐dopa‐induced motor deficits in mice, suggesting that the basal ganglia might contribute to PKD pathology.… read more here.
Keywords: dopamine; proline rich; rich transmembrane; transmembrane protein ... See more keywords
A Role for Transmembrane Protein 16C/Slack Impairment in Excitatory Nociceptive Synaptic Plasticity in the Pathogenesis of Remifentanil-induced Hyperalgesia in Rats.
Sign Up to like & getrecommendations! Published in 2021 at "Neuroscience bulletin"
DOI: 10.1007/s12264-021-00652-5
Abstract: Remifentanil is widely used to control intraoperative pain. However, its analgesic effect is limited by the generation of postoperative hyperalgesia. In this study, we investigated whether the impairment of transmembrane protein 16C (TMEM16C)/Slack is required… read more here.
Keywords: remifentanil; hyperalgesia; slack; remifentanil induced ... See more keywords
A novel transmembrane protein defines the endoplasmic reticulum stress-induced cell death pathway.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.03.017
Abstract: Mitochondrial membrane potential (ΔΨm) maintenance is physiologically critical in cells; its loss causes apoptotic signalling and cell death. Accumulating DNA mutations and unfolded proteins in stressed cells activate signalling pathways for cell death induction. Cancer… read more here.
Keywords: death; stress; cell death; transmembrane protein ... See more keywords
Structure of Human ATG9A, the Only Transmembrane Protein of the Core Autophagy Machinery.
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.107837
Abstract: Autophagy is a catabolic process involving capture of cytoplasmic materials into double-membraned autophagosomes that subsequently fuse with lysosomes for degradation of the materials by lysosomal hydrolases. One of the least understood components of the autophagy… read more here.
Keywords: autophagy machinery; structure; structure human; human atg9a ... See more keywords
Missense variants in the conserved transmembrane M2 protein domain of KCNJ13 associated with retinovascular changes in humans and zebrafish
Sign Up to like & getrecommendations! Published in 2019 at "Experimental Eye Research"
DOI: 10.1016/j.exer.2019.107852
Abstract: Mutations in KCNJ13 are associated with two retinal disorders; Leber congenital amaurosis (LCA) and snowflake vitreoretinal degeneration (SVD). We describe a novel fibrovascular proliferation in the retina of two affected members of a KCNJ13-related LCA… read more here.
Keywords: associated retinovascular; retinovascular changes; missense; conserved transmembrane ... See more keywords
In silico analysis of transmembrane protein 31 (TMEM31) antigen to design novel multiepitope peptide and DNA cancer vaccines against melanoma.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular immunology"
DOI: 10.1016/j.molimm.2019.04.030
Abstract: Multiepitope cancer vaccines are announcing themselves as the future of melanoma treatment. Herein, high immunogenic regions of transmembrane protein 31 (TMEM31) antigen were selected according to cytotoxic T lymphocytes' (CTL) epitopes and major histocompatibility complex… read more here.
Keywords: tmem31 antigen; protein tmem31; multiepitope; cancer ... See more keywords
FhuA: From Iron-Transporting Transmembrane Protein to Versatile Scaffolds through Protein Engineering.
Sign Up to like & getrecommendations! Published in 2023 at "Accounts of chemical research"
DOI: 10.1021/acs.accounts.3c00060
Abstract: ConspectusProtein engineering has emerged as a powerful methodology to tailor the properties of proteins. It empowers the design of biohybrid catalysts and materials, thereby enabling the convergence of materials science, chemistry, and medicine. The choice… read more here.
Keywords: medicine; fhua; iron; transmembrane protein ... See more keywords