Trafficking in Alzheimer’s Disease: Modulation of APP Transport and Processing by the Transmembrane Proteins LRP1, SorLA, SorCS1c, Sortilin, and Calsyntenin
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Neurobiology"
DOI: 10.1007/s12035-017-0806-x
Abstract: The amyloid precursor protein (APP), one key player in Alzheimer’s disease (AD), is extensively processed by different proteases. This leads to the generation of diverging fragments including the amyloid β (Aβ) peptide, which accumulates in… read more here.
Keywords: transmembrane proteins; alzheimer disease; sortilin; sortilin calsyntenin ... See more keywords
Beyond the AMPA receptor: Diverse roles of SynDIG/PRRT brain-specific transmembrane proteins at excitatory synapses
Sign Up to like & getrecommendations! Published in 2021 at "Current opinion in pharmacology"
DOI: 10.1016/j.coph.2021.03.011
Abstract: α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors (AMPARs) are responsible for fast excitatory transmission in the brain. Deficits in synaptic transmission underlie a variety of neurological and psychiatric disorders. However, drugs that target AMPARs are challenging to… read more here.
Keywords: syndig prrt; transmembrane; transmembrane proteins; ampar auxiliary ... See more keywords
In Situ Assembly of Transmembrane Proteins from Expressed and Synthetic Components in Giant Unilamellar Vesicles.
Sign Up to like & getrecommendations! Published in 2022 at "ACS chemical biology"
DOI: 10.1021/acschembio.2c00013
Abstract: Reconstituting functional transmembrane (TM) proteins into model membranes is challenging due to the difficulty of expressing hydrophobic TM domains, which often require stabilizing detergents that can perturb protein structure and function. Recent model systems solve… read more here.
Keywords: transmembrane proteins; assembly transmembrane; expressed synthetic; situ assembly ... See more keywords
Cell-Free Synthesis Goes Electric: Dual Optical and Electronic Biosensor via Direct Channel Integration into a Supported Membrane Electrode.
Sign Up to like & getrecommendations! Published in 2023 at "ACS synthetic biology"
DOI: 10.1021/acssynbio.2c00531
Abstract: Assembling transmembrane proteins on organic electronic materials is one promising approach to couple biological functions to electrical readouts. A biosensing device produced in such a way would enable both the monitoring and regulation of physiological… read more here.
Keywords: transmembrane proteins; cell free; integration; free synthesis ... See more keywords
Steric pressure between glycosylated transmembrane proteins inhibits internalization by endocytosis.
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2215815120
Abstract: Clathrin-mediated endocytosis is essential for the removal of transmembrane proteins from the plasma membrane in all eukaryotic cells. Many transmembrane proteins are glycosylated. These proteins collectively comprise the glycocalyx, a sugar-rich layer at the cell… read more here.
Keywords: transmembrane proteins; transmembrane; ectodomain; glycosylation ... See more keywords
MutHTP: mutations in human transmembrane proteins
Sign Up to like & getrecommendations! Published in 2018 at "Bioinformatics"
DOI: 10.1093/bioinformatics/bty054
Abstract: Motivation Existing sources of experimental mutation data do not consider the structural environment of amino acid substitutions and distinguish between soluble and membrane proteins. They also suffer from a number of further limitations, including data… read more here.
Keywords: human transmembrane; mutations human; muthtp mutations; transmembrane proteins ... See more keywords
The TMCrys server for supporting crystallization of transmembrane proteins
Sign Up to like & getrecommendations! Published in 2019 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btz108
Abstract: Abstract Motivation Due to their special properties, the structures of transmembrane proteins are extremely hard to determine. Several methods exist to predict the propensity of successful completion of the structure determination process. However, available predictors… read more here.
Keywords: crystallization transmembrane; transmembrane proteins; tmcrys server; server supporting ... See more keywords
Transmembrane proteins tetraspanin 4 and CD9 sense membrane curvature
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1101/2022.06.02.494291
Abstract: Multiple membrane shaping and remodelling processes are associated with tetraspanin proteins by yet unknown mechanisms. Tetraspanins constitute a family of proteins with four transmembrane domains present in high copy numbers in every cell type. Prominent… read more here.
Keywords: transmembrane proteins; proteins tetraspanin; oocyte microvilli; membrane curvature ... See more keywords
Enabling QTY Server for Designing Water-Soluble α-Helical Transmembrane Proteins
Sign Up to like & getrecommendations! Published in 2022 at "mBio"
DOI: 10.1128/mbio.03604-21
Abstract: Water-soluble expression and purification are of considerable importance for protein identification and characterization. However, there has been a lack of an effective method for water-soluble expression of membrane proteins, which has severely hampered their studies.… read more here.
Keywords: water soluble; water; server; transmembrane proteins ... See more keywords
Clathrin regulates Wnt/β-catenin signaling by affecting Golgi to plasma membrane transport of transmembrane proteins.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of cell science"
DOI: 10.1242/jcs.244467
Abstract: The canonical Wnt/β-catenin signaling pathway regulates cell proliferation in development and adult tissue homeostasis. Dysregulated signaling contributes to human diseases, in particular cancer. Growing evidence suggests a role for clathrin and/or endocytosis in the regulation… read more here.
Keywords: transmembrane proteins; catenin signaling; catenin; transport ... See more keywords
Field model for multistate lateral diffusion of various transmembrane proteins observed in living Dictyostelium cells
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Cell Science"
DOI: 10.1242/jcs.260280
Abstract: ABSTRACT The lateral diffusion of transmembrane proteins on plasma membranes is a fundamental process for various cellular functions. Diffusion properties specific for individual protein species have been extensively studied, but the common features among protein… read more here.
Keywords: transmembrane proteins; diffusion; lateral diffusion; transmembrane ... See more keywords