SARS-CoV-2 receptor ACE2 is co-expressed with genes related to transmembrane serine proteases, viral entry, immunity and cellular stress
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DOI: 10.1038/s41598-020-78402-2
Abstract: The COVID-19 pandemic resulting from the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which emerged in December 2019 in Wuhan in China has placed immense burden on national economies and global health. At present neither… read more here.
Keywords: serine proteases; serine; cellular stress; transmembrane serine ... See more keywords
Type II transmembrane serine proteases as potential target for anti-influenza drug discovery
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DOI: 10.1080/17460441.2017.1372417
Abstract: ABSTRACT Introduction: The outbreak of an influenza pandemic as well as the continued circulation of seasonal influenza highlights the need for effective antiviral therapies. The emergence of drug-resistant strains further necessitates the development of novel… read more here.
Keywords: serine proteases; type transmembrane; influenza; drug ... See more keywords
Impacts of transmembrane serine protease 4 expression on susceptibility to severe acute respiratory syndrome coronavirus 2
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DOI: 10.1097/cm9.0000000000002443
Abstract: Key Laboratory of Epigenetics and Oncology, The Research Center for Preclinical Medicine, Southwest Medical University, Luzhou, Sichuan 646000, China; Department of Pathology, The Affiliated Huai’an No. 1 People’s Hospital of Nanjing Medical University, Huai’an, Jiangsu… read more here.
Keywords: protease expression; expression susceptibility; transmembrane serine; serine protease ... See more keywords
SLN124, a GalNac‐siRNA targeting transmembrane serine protease 6, in combination with deferiprone therapy reduces ineffective erythropoiesis and hepatic iron‐overload in a mouse model of β‐thalassaemia
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DOI: 10.1111/bjh.17428
Abstract: Beta‐thalassaemia is an inherited blood disorder characterised by ineffective erythropoiesis and anaemia. Consequently, hepcidin expression is reduced resulting in increased iron absorption and primary iron overload. Hepcidin is under the negative control of transmembrane serine… read more here.
Keywords: thalassaemia; ineffective erythropoiesis; iron overload; transmembrane serine ... See more keywords
rs12329760 Polymorphism in Transmembrane Serine Protease 2 Gene and Risk of Coronavirus Disease 2019 Mortality
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DOI: 10.1155/2022/7841969
Abstract: The protease produced by the transmembrane serine protease 2 (TMPRSS2) gene enhances viral infections and has been linked to severe acute respiratory syndrome coronavirus 2 pathogenesis. Therefore, this study evaluated the association between TMPRSS2 and… read more here.
Keywords: transmembrane serine; polymorphism; protease; serine protease ... See more keywords
Dysregulation of Type II Transmembrane Serine Proteases and Ligand-Dependent Activation of MET in Urological Cancers
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DOI: 10.3390/ijms21082663
Abstract: Unlike in normal epithelium, dysregulated overactivation of various proteases have been reported in cancers. Degradation of pericancerous extracellular matrix leading to cancer cell invasion by matrix metalloproteases is well known evidence. On the other hand,… read more here.
Keywords: type transmembrane; transmembrane serine; urological cancers; hgf ... See more keywords
Transmembrane serine protease 2 is a prognostic factor for lung adenocarcinoma
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DOI: 10.3892/ijo.2022.5329
Abstract: Transmembrane serine protease 2 (TMPRSS2) has been intensively investigated during the current Sars-CoV-2 pandemic as a virus activating protease. Furthermore, TMPRSS2 is an oncogenic gene associated with several cancer entities. Co-expression of TMPRSS2 and serpin… read more here.
Keywords: transmembrane serine; serine protease; lung; tmprss2 ... See more keywords