Analysis of the potential impact of durability, timing, and transmission blocking of COVID-19 vaccine on morbidity and mortality
Sign Up to like & getrecommendations! Published in 2021 at "EClinicalMedicine"
DOI: 10.1016/j.eclinm.2021.100863
Abstract: Background COVID-19 vaccines have been approved and made available. While questions of vaccine allocation strategies have received significant attention, important questions remain regarding the potential impact of the vaccine given uncertainties regarding efficacy against transmission,… read more here.
Keywords: transmission; potential impact; durability; transmission blocking ... See more keywords
The transmission-blocking effects of antimalarial drugs revisited: fitness costs and sporontocidal effects of artesunate and sulfadoxine-pyrimethamine.
Sign Up to like & getrecommendations! Published in 2021 at "International journal for parasitology"
DOI: 10.1016/j.ijpara.2020.09.012
Abstract: Assays used to evaluate the transmission-blocking activity of antimalarial drugs are largely focused on their potential to inhibit or reduce the infectivity of gametocytes, the blood stages of the parasite that are responsible for the… read more here.
Keywords: transmission; artesunate sulfadoxine; sulfadoxine pyrimethamine; blood ... See more keywords
Molecular definition of multiple sites of antibody inhibition of malaria transmission-blocking vaccine antigen Pfs25
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/s41467-017-01924-3
Abstract: The Plasmodium falciparum Pfs25 protein (Pfs25) is a leading malaria transmission-blocking vaccine antigen. Pfs25 vaccination is intended to elicit antibodies that inhibit parasite development when ingested by Anopheles mosquitoes during blood meals. The Pfs25 three-dimensional… read more here.
Keywords: blocking vaccine; malaria transmission; vaccine antigen; transmission blocking ... See more keywords
Multistage and transmission-blocking targeted antimalarials discovered from the open-source MMV Pandemic Response Box
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-020-20629-8
Abstract: Chemical matter is needed to target the divergent biology associated with the different life cycle stages of Plasmodium . Here, we report the parallel de novo screening of the Medicines for Malaria Venture (MMV) Pandemic Response… read more here.
Keywords: pandemic response; response box; transmission blocking;
Structure and function of a malaria transmission blocking vaccine targeting Pfs230 and Pfs230-Pfs48/45 proteins
Sign Up to like & getrecommendations! Published in 2020 at "Communications Biology"
DOI: 10.1038/s42003-020-01123-9
Abstract: Proteins Pfs230 and Pfs48/45 are Plasmodium falciparum transmission-blocking (TB) vaccine candidates that form a membrane-bound protein complex on gametes. The biological role of Pfs230 or the Pfs230-Pfs48/45 complex remains poorly understood. Here, we present the… read more here.
Keywords: pfs230; blocking vaccine; pfs230 pfs48; transmission blocking ... See more keywords
The need to compare: assessing the level of agreement of three high-throughput assays against Plasmodium falciparum mature gametocytes
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep45992
Abstract: Whole-cell High-Throughput Screening (HTS) is a key tool for the discovery of much needed malaria transmission blocking drugs. Discrepancies in the reported outcomes from various HTS Plasmodium falciparum gametocytocidal assays hinder the direct comparison of… read more here.
Keywords: agreement; plasmodium falciparum; transmission blocking; high throughput ... See more keywords
Nanobodies against Pfs230 block Plasmodium falciparum transmission
Sign Up to like & getrecommendations! Published in 2022 at "Biochemical Journal"
DOI: 10.1042/bcj20220554
Abstract: Transmission blocking interventions can stop malaria parasite transmission from mosquito to human by inhibiting parasite infection in mosquitos. One of the most advanced candidates for a malaria transmission blocking vaccine is Pfs230. Pfs230 is the… read more here.
Keywords: nanobodies pfs230; pfs230 block; transmission; falciparum transmission ... See more keywords
Single-cell RNA sequencing of Trypanosoma brucei from tsetse salivary glands unveils metacyclogenesis and identifies potential transmission blocking antigens
Sign Up to like & getrecommendations! Published in 2020 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1914423117
Abstract: Significance African trypanosomes, Trypanosoma brucei spp., are transmitted by the bite of infected tsetse flies. Mammalian vaccines are not available, and diagnosis and treatment remain difficult in the affected remote areas. The transcriptomic analysis of… read more here.
Keywords: metacyclogenesis; tsetse; transmission blocking; cell ... See more keywords
Statistical Methods for Standard Membrane-Feeding Assays to Measure Transmission Blocking or Reducing Activity in Malaria
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the American Statistical Association"
DOI: 10.1080/01621459.2017.1356313
Abstract: ABSTRACT Transmission blocking vaccines for malaria are not designed to directly protect vaccinated people from malaria disease, but to reduce the probability of infecting other people by interfering with the growth of the malaria parasite… read more here.
Keywords: feeding assays; transmission; membrane feeding; transmission blocking ... See more keywords
Novel Transmission-Blocking Antimalarials Identified by High-Throughput Screening of Plasmodium berghei Ookluc
Sign Up to like & getrecommendations! Published in 2023 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.01465-22
Abstract: Safe and effective malaria transmission-blocking chemotherapeutics would allow a community-level approach to malaria control and eradication efforts by targeting the mosquito sexual stage of the parasite life cycle. However, only a single drug, primaquine, is… read more here.
Keywords: plasmodium; transmission; high throughput; drug ... See more keywords
Characterization of Plasmodium berghei Pbg37 as Both a Pre- and Postfertilization Antigen with Transmission-Blocking Potential
Sign Up to like & getrecommendations! Published in 2018 at "Infection and Immunity"
DOI: 10.1128/iai.00785-17
Abstract: Transmission-blocking vaccines (TBVs) interrupting malaria transmission are an integrated tool for malaria eradication. We characterized a sexual-stage-specific gene (PBANKA_060330) from Plasmodium berghei and studied its potential for use as a TBV. ABSTRACT Transmission-blocking vaccines (TBVs)… read more here.
Keywords: transmission; pbg37; plasmodium berghei; transmission blocking ... See more keywords