Impaired cortico-striatal excitatory transmission triggers epilepsy
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DOI: 10.1038/s41467-019-09954-9
Abstract: STXBP1 and SCN2A gene mutations are observed in patients with epilepsies, although the circuit basis remains elusive. Here, we show that mice with haplodeficiency for these genes exhibit absence seizures with spike-and-wave discharges (SWDs) initiated… read more here.
Keywords: transmission; transmission triggers; mice; cortico striatal ... See more keywords