Histone H3 lysine 4 trimethylation in sperm is transmitted to the embryo and associated with diet-induced phenotypes in the offspring.
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DOI: 10.1016/j.devcel.2021.01.014
Abstract: A father's lifestyle impacts offspring health; yet, the underlying molecular mechanisms remain elusive. We hypothesized that a diet that changes methyl donor availability will alter the sperm and embryo epigenomes to impact embryonic gene expression… read more here.
Keywords: histone lysine; lysine trimethylation; gene expression; transmitted embryo ... See more keywords