Short-term facilitation and depression of transmitter release at amphibian sympathetic ganglionic cells – Mathematical/computational modeling
Sign Up to like & getrecommendations! Published in 2017 at "Brain Research"
DOI: 10.1016/j.brainres.2017.06.028
Abstract: There have been few investigations of the short-term plasticity of synaptic transmission at amphibian sympathetic ganglionic cells where the frequency of miniature excitatory postsynaptic potentials is too low to measure an accurate quantum size. This… read more here.
Keywords: equation; ganglionic cells; short term; transmitter release ... See more keywords
Forskolin and protein kinase inhibitors differentially affect hair cell potassium currents and transmitter release at the cytoneural junction in the isolated frog labyrinth
Sign Up to like & getrecommendations! Published in 2017 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2017.05.039
Abstract: The post-transductional elaboration of sensory input at the frog semicircular canal has been studied by correlating the effects of drugs that interfere with phosphorylation processes on: (i) potassium conductances in isolated hair cell and (ii)… read more here.
Keywords: transmitter release; hair cell; kinase; hair ... See more keywords
Simulations of active zone structure and function at mammalian NMJs predict that loss of calcium channels alone is not sufficient to replicate LEMS effects.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of neurophysiology"
DOI: 10.1152/jn.00404.2022
Abstract: Lambert-Eaton myasthenic syndrome (LEMS) is an autoimmune-mediated neuromuscular disease thought to be caused by autoantibodies against P/Q-type voltage-gated calcium channels (VGCCs), which attack and reduce the number of VGCCs within transmitter release sites (active zones;… read more here.
Keywords: calcium channels; alone sufficient; transmitter release; lems effects ... See more keywords
Dynamic Factors for Transmitter Release at Small Presynaptic Boutons Revealed by Direct Patch-Clamp Recordings
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2019.00269
Abstract: Small size of an axon and presynaptic structures have hindered direct functional analysis of axonal signaling and transmitter release at presynaptic boutons in the central nervous system. However, recent technical advances in subcellular patch-clamp recordings… read more here.
Keywords: transmitter release; clamp recordings; patch clamp; presynaptic boutons ... See more keywords
Modeling analysis of subthreshold voltage signaling along hippocampal mossy fiber axons
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2022.966636
Abstract: Axons are classically thought of as electrically well isolated from other parts of the neurons due to the shape of a long cable-like structure. In contrast to this classical view on axonal compartmentalization, recent studies… read more here.
Keywords: calcium; subthreshold voltage; voltage signaling; voltage ... See more keywords
Microphysiological Modeling of the Structure and Function of Neuromuscular Transmitter Release Sites
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Synaptic Neuroscience"
DOI: 10.3389/fnsyn.2022.917285
Abstract: The general mechanism of calcium-triggered chemical transmitter release from neuronal synapses has been intensely studied, is well-known, and highly conserved between species and synapses across the nervous system. However, the structural and functional details within… read more here.
Keywords: structure function; microphysiological modeling; transmitter; modeling structure ... See more keywords