The 1-β-methyl group confers a lower affinity of l,d-transpeptidase LdtMt2 for ertapenem than for imipenem.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.01.082
Abstract: L,D-transpeptidases, widely distributed in bacteria and even in the difficult-to-treat ESKAPE pathogens, can confer antibacterial resistance against the traditional β-lactam antibiotics through bypass of the 4 → 3 transpeptide linkage. LdtMt2, a l,d-transpeptidase in Mycobacteria tuberculosis, is… read more here.
Keywords: transpeptidase; ertapenem; affinity; methyl group ... See more keywords
Peptidoglycan editing by a specific ld-transpeptidase controls the muramidase-dependent secretion of typhoid toxin
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DOI: 10.1038/s41564-018-0248-x
Abstract: Protein secretion mechanisms are essential for the virulence of most bacterial pathogens. Typhoid toxin is an essential virulence factor for Salmonella Typhi, the cause of typhoid fever in humans. This toxin is unique in that… read more here.
Keywords: secretion typhoid; transpeptidase; toxin; typhoid toxin ... See more keywords
LdtC Is a Key l,d-Transpeptidase for Peptidoglycan Assembly in Mycobacterium smegmatis
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DOI: 10.1128/jb.00424-22
Abstract: Mycobacteria have several enzymes to catalyze nonclassical 3-3 linkages in the cell wall peptidoglycan. Understanding the biology of these cross-links is important for the development of antibiotic therapies to target peptidoglycan biosynthesis. Our work provides… read more here.
Keywords: cross links; ldtc; smegmatis; cross ... See more keywords
LdtMav2, a nonclassical transpeptidase and susceptibility of Mycobacterium avium to carbapenems
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DOI: 10.2217/fmb-2016-0208
Abstract: Aim: Mycobacterium avium infections, especially in immune-compromised individuals, present a significant challenge as therapeutic options are limited. In this study, we investigated if M. avium genome encodes nonclassical transpeptidases and if newer carbapenems are effective… read more here.
Keywords: transpeptidase; avium; nonclassical transpeptidase; transpeptidase avium ... See more keywords
Isolation, Purification and Characterization of L,D-transpeptidase 2 from Mycobacterium tuberculosis
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DOI: 10.32607/20758251-2019-11-1-23-28
Abstract: L,D-transpeptidase 2 from Mycobacterium tuberculosis plays a key role in the formation of nonclassical 3-3 peptidoglycan cross-links in a pathogen’s cell wall making it resistant to a broad range of penicillin antibiotics. The conditions of… read more here.
Keywords: transpeptidase; transpeptidase mycobacterium; isolation purification; tuberculosis ... See more keywords
Allosteric cooperation in β-lactam binding to a non-classical transpeptidase
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DOI: 10.7554/elife.73055
Abstract: L,D-transpeptidase function predominates in atypical 3 → 3 transpeptide networking of peptidoglycan (PG) layer in Mycobacterium tuberculosis. Prior studies of L,D-transpeptidases have identified only the catalytic site that binds to peptide moiety of the PG… read more here.
Keywords: allosteric cooperation; catalytic site; site; lactam ... See more keywords