Co-inhibition of immunoproteasome subunits LMP2 and LMP7 enables prevention of transplant arteriosclerosis.
Sign Up to like & getrecommendations! Published in 2022 at "Cardiovascular research"
DOI: 10.1093/cvr/cvac181
Abstract: AIMS The loss of vascular wall cells in allotransplanted arteries is the initial event leading to transplant arteriosclerosis (TA) and ensuing loss of allograft function. Pharmacological agents able to prevent TA are currently lacking. We… read more here.
Keywords: immunoproteasome; inhibition; transplant arteriosclerosis; rejection ... See more keywords
Direct Impact of Human Platelets on the Development of Transplant Arteriosclerosis.
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DOI: 10.1097/tp.0000000000003935
Abstract: BACKGROUND Platelets play an important role in the pathogenesis of inflammatory and proliferative vascular changes. The aim of this study was to investigate whether human platelets are able to induce transplant arteriosclerosis in a humanized… read more here.
Keywords: human platelets; transplant arteriosclerosis; development transplant; activated human ... See more keywords
Impact of Local Alloimmunity and Recipient Cells in Transplant Arteriosclerosis
Sign Up to like & getrecommendations! Published in 2020 at "Circulation Research"
DOI: 10.1161/circresaha.119.316470
Abstract: Supplemental Digital Content is available in the text. Rationale: Transplant arteriosclerosis is the major limitation to long-term survival of solid organ transplantation. Although both immune and nonimmune cells have been suggested to contribute to this… read more here.
Keywords: impact local; transplant arteriosclerosis; single cell; disease ... See more keywords