Transplant‐associated thrombotic microangiopathy: an unresolved complication of unrelated allogeneic transplant for hematologic diseases
Sign Up to like & getrecommendations! Published in 2017 at "Hematological Oncology"
DOI: 10.1002/hon.2346
Abstract: We read with great interest the study by Ye and colleagues regarding risk factors and prognosis of transplant‐associated thrombotic microangiopathy (TA‐TMA). Indeed, TA‐TMA represents a devastating and life‐threatening complication occurring more frequently in allogeneic compared… read more here.
Keywords: associated thrombotic; transplant associated; complication; transplant ... See more keywords
End Organ Damage Following Refractory/Recurrent Transplant Associated Thrombotic Microangiopathy (TA-TMA) in Pediatric Patients Undergoing Autologous Hematopoietic Cell Transplantation
Sign Up to like & getrecommendations! Published in 2019 at "Biology of Blood and Marrow Transplantation"
DOI: 10.1016/j.bbmt.2018.12.431
Abstract: Background Transplant associated thrombotic microangiopathy (TA-TMA) is a known complication of autologous hematopoietic cell transplantation (aHCT), particularly in neuroblastoma. We describe our single institution experience of TA-TMA after aHCT in children. Methods Data were extracted… read more here.
Keywords: transplant associated; associated thrombotic; thrombotic microangiopathy; transplantation ... See more keywords
Linking Complement Activation, Coagulation, and Neutrophils in Transplant-Associated Thrombotic Microangiopathy.
Sign Up to like & getrecommendations! Published in 2019 at "Thrombosis and haemostasis"
DOI: 10.1055/s-0039-1692721
Abstract: Transplant-associated thrombotic microangiopathy (TA-TMA) is a severe and life-threatening complication of hematopoietic cell transplantation (HCT) that often coincides with graft-versus-host-disease (GVHD). Although endothelial damage seems to be the common denominator for both disorders, the role… read more here.
Keywords: coagulation; associated thrombotic; activation coagulation; transplant associated ... See more keywords
What complements complement in transplant‐associated thrombotic microangiopathy?
Sign Up to like & getrecommendations! Published in 2022 at "British Journal of Haematology"
DOI: 10.1111/bjh.18402
Abstract: Transplant‐associated thrombotic microangiopathy remains a lethal complication of haematopoietic stem cell transplant and not all patients respond to terminal complement inhibitors. Qi et al. show that hypoxia‐inducible factor‐1α (HIF‐1α) may be a previously unrecognized driver… read more here.
Keywords: thrombotic microangiopathy; transplant; associated thrombotic; complements complement ... See more keywords
Eculizumab in Transplant-Associated Thrombotic Microangiopathy
Sign Up to like & getrecommendations! Published in 2017 at "Clinical and Applied Thrombosis/Hemostasis"
DOI: 10.1177/1076029615599439
Abstract: Introduction: Transplant-associated thrombotic microangiopathy (TA-TMA) is a rare entity with no standard of care and high mortality, despite the use of plasma exchange. Methods: Using specific search terms, all cases having TA-TMA treated with eculizumab… read more here.
Keywords: associated thrombotic; transplant associated; transplant; eculizumab ... See more keywords
Interferon-complement loop in transplant-associated thrombotic microangiopathy.
Sign Up to like & getrecommendations! Published in 2020 at "Blood advances"
DOI: 10.1182/bloodadvances.2020001515
Abstract: Transplant-associated thrombotic microangiopathy (TA-TMA) is an important cause of morbidity and mortality after hematopoietic stem cell transplantation (HSCT). The complement inhibitor eculizumab improves TA-TMA, but not all patients respond to therapy, prompting a search for… read more here.
Keywords: associated thrombotic; transplant associated; interferon; complement ... See more keywords
Clinical Characteristics of Transplant-associated Encephalopathy in Children
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Korean Medical Science"
DOI: 10.3346/jkms.2017.32.3.457
Abstract: We aimed to analyze characteristics of encephalopathy after both hematopoietic stem cell and solid organ pediatric transplantation. We retrospectively reviewed medical records of 662 pediatric transplant recipients (201 with liver transplantation [LT], 55 with heart… read more here.
Keywords: encephalopathy common; transplant associated; transplant; associated encephalopathy ... See more keywords
Early Elevation of Complement Factor Ba Is a Predictive Biomarker for Transplant-Associated Thrombotic Microangiopathy
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.695037
Abstract: Transplant-associated thrombotic microangiopathy (TA-TMA) is a fatal complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Previous reports suggest that TA-TMA is caused by complement activation by complement-related genetic variants; however, this needs to be verified,… read more here.
Keywords: associated thrombotic; transplant associated; complement; tma ... See more keywords
A systematic review of diagnostic, prognostic, and risk blood and urine biomarkers of transplant-associated thrombotic microangiopathy
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1064203
Abstract: Transplant-associated thrombotic microangiopathy (TA-TMA) is an increasingly recognized complication of allogeneic and autologous hematopoietic cellular therapy (HCT), associated with significant morbidity and mortality. Although the central drivers of the disease are thought to be endothelial… read more here.
Keywords: thrombotic microangiopathy; associated thrombotic; systematic review; risk ... See more keywords
Transplant-Associated Thrombotic Microangiopathy in the Context of Allogenic Hematopoietic Stem Cell Transplantation: Where We Stand
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24021159
Abstract: Transplant-associated thrombotic microangiopathy (TA-TMA) constitutes a significant contributor to the increased morbidity and mortality after allogenic hematopoietic stem cell transplantation (allo-HSCT). TA-TMA is a heterogenous disease, characterized by the triad of endothelial cell activation, complement… read more here.
Keywords: cell; thrombotic microangiopathy; associated thrombotic; allogenic hematopoietic ... See more keywords