On the role of the immunoproteasome in transplant rejection
Sign Up to like & getrecommendations! Published in 2018 at "Immunogenetics"
DOI: 10.1007/s00251-018-1084-0
Abstract: The immunoproteasome is expressed in cells of hematopoietic origin and is induced during inflammation by IFN-γ. Targeting the immunoproteasome with selective inhibitors has been shown to be therapeutically effective in pre-clinical models for autoimmune diseases, colitis-associated… read more here.
Keywords: immunoproteasome transplant; transplantation; transplant rejection; immunoproteasome inhibition ... See more keywords
Combined treatment with vitamin D3 and antibody agents suppresses secondary heart transplant rejection in the early postoperative period.
Sign Up to like & getrecommendations! Published in 2020 at "Transplant immunology"
DOI: 10.1016/j.trim.2020.101270
Abstract: BACKGROUND Accelerated transplant rejection mediated by donor reactive memory T cells is another barrier to the induction of graft tolerance. The aim of this study was to investigate the immunosuppressing effects of vitamin D (1,25(OH)2D3),… read more here.
Keywords: secondary heart; treatment; rejection; transplant rejection ... See more keywords
Macrophages in transplant rejection.
Sign Up to like & getrecommendations! Published in 2022 at "Transplant immunology"
DOI: 10.1016/j.trim.2022.101536
Abstract: Transplant rejection is one of the primary factors leading to loss of allograft function, and macrophages are involved in allograft rejection. Macrophages polarize into different phenotypes according to stimulation by different external factors. Different types… read more here.
Keywords: macrophages transplant; immunology; rejection macrophages; rejection ... See more keywords
A CRISPR-based assay for the detection of opportunistic infections post-transplantation and for the monitoring of transplant rejection
Sign Up to like & getrecommendations! Published in 2020 at "Nature Biomedical Engineering"
DOI: 10.1038/s41551-020-0546-5
Abstract: In organ transplantation, infection and rejection are major causes of graft loss. They are linked by the net state of immunosuppression. To diagnose and treat these conditions earlier, and to improve long-term patient outcomes, refined… read more here.
Keywords: transplantation monitoring; rejection; transplantation; transplant rejection ... See more keywords
Investigational drugs for the treatment of kidney transplant rejection
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Investigational Drugs"
DOI: 10.1080/13543784.2022.2130751
Abstract: ABSTRACT Introduction Kidney transplant rejection remains an important clinical problem despite the development of effective immunosuppressive therapy. Two major types of rejection are recognized, T-cell-mediated rejection (TCMR) and antibody-mediated rejection (ABMR), which have a different… read more here.
Keywords: investigational drugs; kidney transplant; treatment; transplant rejection ... See more keywords
Suppression of liver transplant rejection by anti-donor MHC antibodies via depletion of donor immunogenic dendritic cells
Sign Up to like & getrecommendations! Published in 2020 at "International Immunology"
DOI: 10.1093/intimm/dxaa076
Abstract: Abstract Background We previously found two distinct passenger dendritic cell (DC) subsets in the rat liver that played a central role in the liver transplant rejection. In addition, a tolerance-inducing protocol, donor-specific transfusion (DST), triggered… read more here.
Keywords: anti donor; donor; liver transplant; dst ... See more keywords
Acute Corneal Transplant Rejection After Severe Acute Respiratory Syndrome Coronavirus 2 mRNA-1273 Vaccination
Sign Up to like & getrecommendations! Published in 2021 at "Cornea"
DOI: 10.1097/ico.0000000000002886
Abstract: Purpose: The purpose of this article was to report a case of full-thickness corneal transplant rejection 3 days after immunization with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Moderna mRNA-1273 vaccine. Methods: Case Report.… read more here.
Keywords: transplant rejection; corneal transplant; vaccination; rejection ... See more keywords
Seasonal Variability Precipitating Hand Transplant Rejection?
Sign Up to like & getrecommendations! Published in 2017 at "Transplantation"
DOI: 10.1097/tp.0000000000001877
Abstract: An important distinction between vascularized composite allotransplantation (VCA) and solid organ transplantation is exposure of the transplant to the external environment. The implications of seasonal climate variations and environmental exposure on the outcome of VCA… read more here.
Keywords: seasonal variability; hand transplant; rejection; transplant rejection ... See more keywords
The Role of Dynamic DNA Methylation in Liver Transplant Rejection in Children
Sign Up to like & getrecommendations! Published in 2022 at "Transplantation Direct"
DOI: 10.1097/txd.0000000000001394
Abstract: Background Transcriptional regulation of liver transplant (LT) rejection may reveal novel predictive and therapeutic targets. Purpose To test the role of differential DNA methylation in children with biopsy-proven acute cellular rejection (rejectors, R) after LT.… read more here.
Keywords: liver transplant; dna methylation; dmcs; transplant rejection ... See more keywords
Acute renal transplant rejection following nivolumab therapy for metastatic melanoma
Sign Up to like & getrecommendations! Published in 2021 at "BMJ Case Reports"
DOI: 10.1136/bcr-2020-238037
Abstract: Cancers can develop the ability to evade immune recognition and destruction. Immune checkpoint inhibitors (ICIs) are drugs targeting these immune evasion mechanisms. ICIs have significantly improved outcomes in several cancers including metastatic melanoma. However, data… read more here.
Keywords: transplant; acute renal; metastatic melanoma; transplant rejection ... See more keywords
The Most Promising Biomarkers of Allogeneic Kidney Transplant Rejection
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Immunology Research"
DOI: 10.1155/2022/6572338
Abstract: Clinical transplantology is a constantly evolving field of medicine. Kidney transplantation has become standard clinical practice, and it has a significant impact on reducing mortality and improving the quality of life of patients. Allogenic transplantation… read more here.
Keywords: kidney; promising biomarkers; kidney transplant; transplant rejection ... See more keywords