In situ repurposing of dendritic cells with CRISPR/Cas9-based nanomedicine to induce transplant tolerance.
Sign Up to like & getrecommendations! Published in 2019 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2019.119302
Abstract: Organ transplantation is the only effective method to treat end-stage organ failure. However, it is continuously plagued by immune rejection, which is mostly caused by T cell-mediated reactions. Dendritic cells (DCs) are professional antigen-presenting cells,… read more here.
Keywords: crispr cas9; gcd40; transplant; transplant tolerance ... See more keywords
Host Expression of the CD8 Treg/NK Cell Restriction Element Qa-1 is Dispensable for Transplant Tolerance
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-11780-2
Abstract: Disruption of the non-classical Major Histocompatibility Complex (MHC) Ib molecule Qa-1 impairs CD8 Treg and natural killer (NK) cell function and promotes a lupus-like autoimmune disease. This immune perturbation would be expected to enhance anti-transplant… read more here.
Keywords: cd8 treg; transplant tolerance; cell; transplant ... See more keywords
Transient Anti-CD45RC mAb Treatment Induces Specific Transplant Tolerance Through Potentiation of Tregs
Sign Up to like & getrecommendations! Published in 2017 at "Transplantation"
DOI: 10.1097/01.tp.0000520346.17326.53
Abstract: Introduction: The main goal in transplantation is to induce specific ra than general immunosuppression. The CD45 protein is an essential regu of T and B cell antigen receptor signaling. We have previously shown T cells… read more here.
Keywords: treatment; cd45rc mab; transplant tolerance; cd45rc ... See more keywords
Humanization and Pre-Clinical Validation of an Anti-HLA-A*02: 01 Chimeric Antigen Receptor for use with Regulatory T cells to Enhance Transplant Tolerance.
Sign Up to like & getrecommendations! Published in 2018 at "Transplantation"
DOI: 10.1097/01.tp.0000542905.98105.1f
Abstract: Introduction Achieving transplant tolerance with regulatory T cell (Treg) adoptive immunotherapy is currently under investigation as a therapy to reduce graft rejection and improve long-term outcomes. Traditional approaches involve the of polyclonal Tregs, which are… read more here.
Keywords: tregs; hla; transplant tolerance; antigen ... See more keywords
Chimerism, Transplant Tolerance and Beyond.
Sign Up to like & getrecommendations! Published in 2019 at "Transplantation"
DOI: 10.1097/tp.0000000000002711
Abstract: The present review discusses current developments in tolerance induction for solid organ transplantation with a particular emphasis on chimerism-based approaches. It explains the basic mechanisms of chimerism-based tolerance and provides an update on ongoing clinical… read more here.
Keywords: chimerism transplant; tolerance; chimerism; transplant tolerance ... See more keywords
Achieving Solid Organ Transplant Tolerance: New Findings, More Questions and the Search Continues.
Sign Up to like & getrecommendations! Published in 2020 at "Transplantation"
DOI: 10.1097/tp.0000000000003264
Abstract: T the specific absence of a harmful alloimmune response to a graft tissue in the absence of immunosuppression, is the main step for successful complete immunosuppressive drug withdrawal following solid organ transplantation. The two most… read more here.
Keywords: tolerance; liver; transplantation; solid organ ... See more keywords
Apheresis of Deceased Donors as a New Source of Mobilized Peripheral Blood Hematopoietic Stem Cells for Transplant Tolerance
Sign Up to like & getrecommendations! Published in 2022 at "Transplantation"
DOI: 10.1097/tp.0000000000004288
Abstract: Background. Solid organ transplantation is the therapy of choice for many patients with end-stage organ failure; however, recipients must remain on lifelong immunosuppression, leaving them susceptible to infections and cancer. The study of transplant tolerance… read more here.
Keywords: apheresis; tolerance; peripheral blood; transplant tolerance ... See more keywords
Regulatory B Cell‐Dependent Islet Transplant Tolerance Is Also Natural Killer Cell Dependent
Sign Up to like & getrecommendations! Published in 2017 at "American Journal of Transplantation"
DOI: 10.1111/ajt.14265
Abstract: Immunologic tolerance to solid organ and islet cell grafts has been achieved in various rodent models by using antibodies directed at CD45RB and Tim‐1. We have shown that this form of tolerance depends on regulatory… read more here.
Keywords: tolerance; islet; natural killer; cell dependent ... See more keywords
Ablation of interferon regulatory factor 4 in T cells induces “memory” of transplant tolerance that is irreversible by immune checkpoint blockade
Sign Up to like & getrecommendations! Published in 2019 at "American Journal of Transplantation"
DOI: 10.1111/ajt.15196
Abstract: Achieving transplant tolerance remains the ultimate goal in the field of organ transplantation. We demonstrated previously that ablation of the transcription factor interferon regulatory factor 4 (IRF4) in T cells induced heart transplant acceptance by… read more here.
Keywords: checkpoint blockade; transplant tolerance; cell; factor ... See more keywords
Transplant Tolerance, Not Only Clonal Deletion
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.810798
Abstract: The quest to understand how allogeneic transplanted tissue is not rejected and how tolerance is induced led to fundamental concepts in immunology. First, we review the research that led to the Clonal Deletion theory in… read more here.
Keywords: clonal deletion; regulatory cells; tolerance; transplant tolerance ... See more keywords