Upregulation of HIF‐1α contributes to complement activation in transplantation‐associated thrombotic microangiopathy
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DOI: 10.1111/bjh.18377
Abstract: Transplantation‐associated thrombotic microangiopathy (TA‐TMA) is a severe complication of haematopoietic stem cell transplantation (HSCT). Complement activation is involved in the development of TA‐TMA. However, the underlying mechanism is unclear. Therefore, 21 samples of TA‐TMA and… read more here.
Keywords: transplantation associated; complement activation; associated thrombotic; hif ... See more keywords
Jugular venous congestion during off‐pump lung transplantation is not associated with an increased risk of postoperative delirium
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DOI: 10.1111/ctr.14794
Abstract: Delirium occurs frequently after lung transplantation and is associated with poor clinical outcomes. Significantly prolonged jugular venous congestion (JVC) occurs during off‐pump lung transplantation and is thought to impair cerebral perfusion. Our study aimed to… read more here.
Keywords: lung transplantation; jugular venous; transplantation associated; delirium ... See more keywords
Immunotherapy for transplantation-associated viral infections
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DOI: 10.1172/jci90599
Abstract: Cytomegalovirus (CMV) and Epstein-Barr virus (EBV) infections following allogeneic hematopoietic stem cell transplantation (HSCT) are a major cause of morbidity and mortality. Early clinical trials demonstrate that adoptive transfer of donor-derived virus-specific T cells to… read more here.
Keywords: immunotherapy transplantation; associated viral; transplantation associated; virus specific ... See more keywords
Narsoplimab, a Mannan-Binding Lectin-Associated Serine Protease-2 Inhibitor, for the Treatment of Adult Hematopoietic Stem-Cell Transplantation–Associated Thrombotic Microangiopathy
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DOI: 10.1200/jco.21.02389
Abstract: PURPOSE Hematopoietic stem-cell transplantation–associated thrombotic microangiopathy (HSCT-TMA) is a serious complication with significant mortality and no approved therapy. HSCT-TMA results from endothelial injury, which activates the lectin pathway of complement. Narsoplimab (OMS721), an inhibitor of… read more here.
Keywords: stem cell; transplantation associated; associated thrombotic; cell transplantation ... See more keywords