Transmembrane Domain Single-Nucleotide Polymorphisms Impair Expression and Transport Activity of ABC Transporter ABCG2
Sign Up to like & getrecommendations! Published in 2017 at "Pharmaceutical Research"
DOI: 10.1007/s11095-017-2127-1
Abstract: PurposeTo study the function and expression of nine naturally occurring single-nucleotide polymorphisms (G406R, F431L, S441N, P480L, F489L, M515R, L525R, A528T and T542A) that are predicted to reside in the transmembrane regions of the ABC transporter… read more here.
Keywords: single nucleotide; transport; expression; abcg2 ... See more keywords
Functional analysis of whether the glycine residue of the GMN motif of the Arabidopsis MRS2/MGT/CorA-type Mg2+ channel protein AtMRS2-11 is critical for Mg2+ transport activity.
Sign Up to like & getrecommendations! Published in 2020 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2020.108673
Abstract: Magnesium (Mg2+) plays a critical role in many physiological processes. The AtMRS2/MGT family, which contains nine Arabidopsis genes (and two pseudogenes), belongs to a eukaryotic subset of the CorA superfamily of divalent cation transporters. AtMRS2-11/MGT10… read more here.
Keywords: gmn motif; mg2; transport activity; mg2 transport ... See more keywords
Enhancing K+ transport activity and selectivity of synthetic K+ channels via electron-donating effects.
Sign Up to like & getrecommendations! Published in 2020 at "Chemical communications"
DOI: 10.1039/c9cc08396k
Abstract: A minor alteration in structure of a previously reported synthetic K+ channel via replacing the electron-withdrawing group with an electron-donating group leads to enhancement in activity by 160% and in selectivity by >50%. As a… read more here.
Keywords: transport activity; electron donating; selectivity; enhancing transport ... See more keywords
CPK32-mediated phosphorylation is essential for the ammonium transport activity of AMT1;1 in Arabidopsis roots.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of experimental botany"
DOI: 10.1093/jxb/eraa249
Abstract: Protein kinase-mediated phosphorylation modulates the absorption of many nutrients in plants. CALCIUM-DEPENDENT PROTEIN KINASES (CPKs) are key players in plant signaling to translate calcium signals into diverse physiological responses. However, the regulatory role of CPKs… read more here.
Keywords: mediated phosphorylation; transport activity; ammonium; ammonium transport ... See more keywords
MAMP-elicited changes in amino acid transport activity contribute to restricting bacterial growth.
Sign Up to like & getrecommendations! Published in 2022 at "Plant physiology"
DOI: 10.1093/plphys/kiac217
Abstract: Plants live under the constant challenge of microbes that probe the environment in search of potential hosts. Plant cells perceive microbe-associated molecular patterns (MAMPs) from incoming microbes and activate defense responses that suppress attempted infections.… read more here.
Keywords: bacterial growth; transport activity; mamp; mamp perception ... See more keywords
The Small Protein SgrT Controls Transport Activity of the Glucose-Specific Phosphotransferase System
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Bacteriology"
DOI: 10.1128/jb.00869-16
Abstract: ABSTRACT The bacterial small RNA (sRNA) SgrS has been a fruitful model for discovery of novel RNA-based regulatory mechanisms and new facets of bacterial physiology and metabolism. SgrS is one of only a few characterized… read more here.
Keywords: sgrt; activity; protein sgrt; transport activity ... See more keywords
Characterization of Transport Activity of SLC11 Transporters in Xenopus laevis Oocytes by Fluorophore Quenching
Sign Up to like & getrecommendations! Published in 2021 at "SLAS Discovery"
DOI: 10.1177/24725552211004123
Abstract: Membrane proteins are involved in different physiological functions and are the target of pharmaceutical and abuse drugs. Xenopus laevis oocytes provide a powerful heterologous expression system for functional studies of these proteins. Typical experiments investigate… read more here.
Keywords: xenopus laevis; characterization transport; transport; laevis oocytes ... See more keywords
Effect of GenX on P-Glycoprotein, Breast Cancer Resistance Protein, and Multidrug Resistance–Associated Protein 2 at the Blood–Brain Barrier
Sign Up to like & getrecommendations! Published in 2020 at "Environmental Health Perspectives"
DOI: 10.1289/ehp5884
Abstract: Background: Ammonium 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoic acid (GenX) is a replacement for perfluorooctanoic acid in the production of fluoropolymers used in a variety of consumer products. GenX alters fetal development and antibody production and elicits toxic responses in… read more here.
Keywords: genx; brain; transport activity; resistance ... See more keywords
Human ABCB1 with an ABCB11-like degenerate nucleotide binding site maintains transport activity by avoiding nucleotide occlusion
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DOI: 10.1371/journal.pgen.1009016
Abstract: Several ABC exporters carry a degenerate nucleotide binding site (NBS) that is unable to hydrolyze ATP at a rate sufficient for sustaining transport activity. A hallmark of a degenerate NBS is the lack of the… read more here.
Keywords: nucleotide binding; catalytic glutamate; site; activity ... See more keywords
PcNRAMP1 Enhances Cadmium Uptake and Accumulation in Populus × canescens
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23147593
Abstract: Poplars are proposed for the phytoremediation of heavy metal (HM) polluted soil. Characterization of genes involved in HM uptake and accumulation in poplars is crucial for improving the phytoremediation efficiency. Here, Natural Resistance-Associated Macrophage Protein… read more here.
Keywords: uptake accumulation; accumulation; transport activity; populus canescens ... See more keywords
The Post-Pandemic Recovery of Transport Activity: Emerging Mobility Patterns and Repercussions on Future Evolution
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DOI: 10.3390/su13116359
Abstract: The expectations for post-COVID recovery of transport activity point towards a gradual return to normality, once the pandemic is under control and mobility restrictions end. The shock to society and economy has, however, caused a… read more here.
Keywords: mobility; recovery transport; transport activity; transport ... See more keywords