Novel Molecular Mechanism of Excitatory Neurotransmitter Transport Inhibition
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.101
Abstract: Human members of the solute carrier 1 (SLC1) family of transporters take up excitatory neurotransmitters in the brain, mainly glutamate, and amino acids in peripheral organs. Dysregulation of their functions is associated to neurodegenerative disorders… read more here.
Keywords: molecular mechanism; transport inhibition; mechanism; novel molecular ... See more keywords
Structural basis of ion transport and inhibition in ferroportin
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-19458-6
Abstract: Ferroportin is an iron exporter essential for releasing cellular iron into circulation. Ferroportin is inhibited by a peptide hormone, hepcidin. In humans, mutations in ferroportin lead to ferroportin diseases that are often associated with accumulation… read more here.
Keywords: structural basis; transport inhibition; ferroportin; transport ... See more keywords
Structural basis of transport and inhibition of the Plasmodium falciparum transporter PfFNT
Sign Up to like & getrecommendations! Published in 2021 at "EMBO reports"
DOI: 10.15252/embr.202153447
Abstract: In “Structural basis of transport and inhibition of the Plasmodium falciparum transporter PfFNT” by Lyu et al (2021), the authors depict the inhibitor MMV007839 in its hemiketal form in Fig 3A and F, Fig 4C,… read more here.
Keywords: structural basis; basis transport; transport inhibition; transporter pffnt ... See more keywords