Regulation of Drug Transport Proteins—From Mechanisms to Clinical Impact: A White Paper on Behalf of the International Transporter Consortium
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Pharmacology and Therapeutics"
DOI: 10.1002/cpt.2605
Abstract: Membrane transport proteins are involved in the absorption, disposition, efficacy, and/or toxicity of many drugs. Numerous mechanisms (e.g., nuclear receptors, epigenetic gene regulation, microRNAs, alternative splicing, post‐translational modifications, and trafficking) regulate transport protein levels, localization,… read more here.
Keywords: disposition; transport proteins; transporter; transport ... See more keywords
Nuclear transport proteins are secreted by cancer cells and identified as potential novel cancer biomarkers.
Sign Up to like & getrecommendations! Published in 2021 at "International journal of cancer"
DOI: 10.1002/ijc.33832
Abstract: Previous studies have identified increased expression of members of the nuclear transport protein family in cancer cells. Recently, certain nuclear transport proteins have been reported to be secreted by cells and found in the serum.… read more here.
Keywords: nuclear transport; transport proteins; proteins secreted; cancer cells ... See more keywords
Incorporating deep learning with convolutional neural networks and position specific scoring matrices for identifying electron transport proteins
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Computational Chemistry"
DOI: 10.1002/jcc.24842
Abstract: In several years, deep learning is a modern machine learning technique using in a variety of fields with state‐of‐the‐art performance. Therefore, utilization of deep learning to enhance performance is also an important solution for current… read more here.
Keywords: transport proteins; electron transport; deep learning; identifying electron ... See more keywords
Transcript levels of members of the SLC2 and SLC5 families of glucose transport proteins in eel swimbladder tissue: the influence of silvering and the influence of a nematode infection
Sign Up to like & getrecommendations! Published in 2017 at "Fish Physiology and Biochemistry"
DOI: 10.1007/s10695-017-0456-y
Abstract: The rate of glucose metabolism has been shown to be correlated to glucose uptake in swimbladder gas gland cells. Therefore, it is assumed that in the European eel silvering, i.e., the preparation of the eel… read more here.
Keywords: gas gland; transport proteins; family; tissue ... See more keywords
Interaction of Silver Nanoparticles with Plasma Transport Proteins: A Systematic Study on Impacts of Particle Size, Shape and Surface Functionalization.
Sign Up to like & getrecommendations! Published in 2020 at "Chemico-biological interactions"
DOI: 10.1016/j.cbi.2020.109364
Abstract: Metallic nanoparticles are an important and widely used materials in development of nano-enabled medicine. For that reason, their interaction with biological molecules has to be systematically examined, as use of nanoparticles can lead to altered… read more here.
Keywords: silver nanoparticles; interaction silver; plasma transport; surface ... See more keywords
Quantitative proteome analysis reveals changes of membrane transport proteins in Sedum plumbizincicola under cadmium stress.
Sign Up to like & getrecommendations! Published in 2021 at "Chemosphere"
DOI: 10.1016/j.chemosphere.2021.132302
Abstract: Sedum plumbizincicola is an herbaceous species tolerant of excessive cadmium accumulation in above-ground tissues. The implications of membrane proteins, especially integrative membrane proteins, in Cd detoxification of plants have received attention in recent years, but… read more here.
Keywords: membrane proteins; transport proteins; transport; quantitative proteome ... See more keywords
Targeting Glucose Transport Proteins for Diabetes Management: Regulatory Roles of Food-Derived Compounds.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c00817
Abstract: With the rapid rise in prevalence, diabetes mellitus is one of the leading causes of mortality worldwide. Impaired cellular glucose transport is a major contributor to diabetes progression and, thus, an important target for treatment.… read more here.
Keywords: food derived; transport; transport proteins; glucose transport ... See more keywords
Amino acid composition analysis of human secondary transport proteins and implications for reliable membrane topology prediction
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2016.1167622
Abstract: Secondary transporters in humans are a large group of proteins that transport a wide range of ions, metals, organic and inorganic solutes involved in energy transduction, control of membrane potential and osmotic balance, metabolic processes… read more here.
Keywords: amino acid; secondary transport; transport proteins; membrane topology ... See more keywords
Comparative genomics of transport proteins in seven Bacteroides species
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DOI: 10.1371/journal.pone.0208151
Abstract: The communities of beneficial bacteria that live in our intestines, the gut microbiome, are important for the development and function of the immune system. Bacteroides species make up a significant fraction of the human gut… read more here.
Keywords: comparative genomics; probiotic pathogenic; genomics transport; seven bacteroides ... See more keywords
Axonal transport proteins as biomarkers of neurodegeneration?
Sign Up to like & getrecommendations! Published in 2017 at "Biomarkers in medicine"
DOI: 10.2217/bmm-2017-0163
Abstract: Neurodegeneration is a cardinal feature of numerous neurological diseases, yet the mechanisms underlying neurodegeneration are disparate and are not currently fully understood. In addition, the diagnosis of neurodegenerative conditions is often challenging and treatments are… read more here.
Keywords: biomarkers neurodegeneration; transport proteins; axonal transport; proteins biomarkers ... See more keywords
Diabetic Encephalopathy Affecting Mitochondria and Axonal Transport Proteins
Sign Up to like & getrecommendations! Published in 2020 at "Basic and Clinical Neuroscience"
DOI: 10.32598/bcn.11.6.1657.1
Abstract: Introduction: Diabetic encephalopathy is described as any cognitive and memory impairments associated with hippocampal degenerative changes, including the neurodegenerative process and decreased number of living cells. Mitochondrial diabetes (MD) appears following activation of mutant mitochondrial… read more here.
Keywords: diabetic encephalopathy; encephalopathy affecting; transport proteins; affecting mitochondria ... See more keywords