Nanoscale zero-valent iron@mesoporous hydrated silica core-shell particles with enhanced dispersibility, transportability and degradation of chlorinated aliphatic hydrocarbons
Sign Up to like & getrecommendations! Published in 2018 at "Chemical Engineering Journal"
DOI: 10.1016/j.cej.2018.03.011
Abstract: Abstract Nanoscale zero-valent iron@mesoporous hydrated silica core-shell particles (NZVI@mHS CSP) with improved dispersibility, transportability and dechlorination strength were successfully synthesized and tested for the removal of chlorinated aliphatic hydrocarbons from groundwater. The structural, electronic and… read more here.
Keywords: nanoscale zero; silica; hydrated silica; zero valent ... See more keywords
Derivatization of Microcystins Can Increase Target Inhibition while Reducing Cellular Uptake
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Natural Products"
DOI: 10.1021/acs.jnatprod.4c00688
Abstract: Microcystins, a large family of nonribosomal cyclic heptapeptides known for their hepatotoxicity, are among the best-studied cyanobacterial toxins. Recently, they have been discussed as leads for the development of anticancer drug substances. Their main mode-of-action… read more here.
Keywords: phosphatase inhibition; inhibition; target inhibition; transportability ... See more keywords
Structural Features Affecting the Interactions and Transportability of LAT1-Targeted Phenylalanine Drug Conjugates
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.2c00594
Abstract: L-type amino acid transporter 1 (LAT1) transfers essential amino acids across cell membranes. Owing to its predominant expression in the blood–brain barrier and tumor cells, LAT1 has been exploited for drug delivery and targeting to… read more here.
Keywords: bond; lat1 targeted; transportability; drug ... See more keywords
Cross-site transportability of an explainable artificial intelligence model for acute kidney injury prediction
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-19551-w
Abstract: Artificial intelligence (AI) has demonstrated promise in predicting acute kidney injury (AKI), however, clinical adoption of these models requires interpretability and transportability. Non-interoperable data across hospitals is a major barrier to model transportability. Here, we… read more here.
Keywords: kidney injury; cross site; model; acute kidney ... See more keywords
Clarifying Contradictions: Transportability in 17OHP-C Trials and Preterm Birth Outcomes Using Doubly Debiased Machine Learning.
Sign Up to like & getrecommendations! Published in 2025 at "American journal of epidemiology"
DOI: 10.1093/aje/kwaf202
Abstract: Following the Meis et al. trial that identified a benefit of 17-alpha-hydroxyprogesterone caproate (17OHP-C) in reducing the risk of recurrent preterm birth (PTB) (risk difference (RD) -18.6%, 95% confidence interval (CI): -28.2%, -9.2%), a confirmatory… read more here.
Keywords: debiased machine; trial; doubly debiased; preterm birth ... See more keywords
Transportability Methods for Time-to-Event Outcomes: Application in Adjuvant Colon Cancer Trials.
Sign Up to like & getrecommendations! Published in 2022 at "JCO clinical cancer informatics"
DOI: 10.1200/cci.22.00088
Abstract: PURPOSE Differences in the benefits of treatment on 5-year overall survival have been observed in 12 randomized phase III colon cancer adjuvant clinical trials from the ACCENT group. We investigated the reasons for these differences… read more here.
Keywords: one trial; time; transportability; trial ... See more keywords
Transportability of Conclusions From Confined Field Trials: A Case Study Using the Virus Resistant Transgenic Bean Developed in Brazil
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2020.00815
Abstract: The conceptual framework for Data Transportability, builds on the premise that well-designed studies conducted for the environmental and food/feed risk assessment of transgenic crops may be transportable across geographies. Beyond individual data, provided that certain… read more here.
Keywords: resistant transgenic; virus resistant; transgenic bean; transportability ... See more keywords