Abstract 4660: Molecular mechanisms by which a bioactivated human carcinogen is transported to target tissues
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DOI: 10.1158/1538-7445.am2019-4660
Abstract: Aristolochic acid (AA) is a potent human carcinogen and nephrotoxin found in preparations of Aristolochia plants used in Chinese Traditional Medicine. Following biotransformation to form N-sulfonyloxyaristolactam (AL-I-NOSO3), this intermediate undergoes heterolytic cleavage of the sulfate… read more here.
Keywords: transported target; human carcinogen; hsa; target tissues ... See more keywords