Flipping and other astonishing transporter dance moves in fungal drug resistance
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DOI: 10.1002/bies.202200035
Abstract: In all domains of life, transmembrane proteins from the ATP‐binding cassette (ABC) transporter family drive the translocation of diverse substances across lipid bilayers. In pathogenic fungi, the ABC transporters of the pleiotropic drug resistance (PDR)… read more here.
Keywords: transporter; resistance; astonishing transporter; flipping astonishing ... See more keywords
Overexpression of the sulfate transporter‐encoding SULTR2 increases chromium accumulation in Chlamydomonas reinhardtii
Sign Up to like & getrecommendations! Published in 2023 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.28350
Abstract: Hexavalent chromium [Cr(Ⅵ)] is a highly toxic contaminant in aquatic systems, and microalgae represent promising bioremediators of metal‐containing wastewater. However, the metal‐binding capacity of algal cells is limited. Therefore, we improved the cellular Cr(Ⅵ) biosorption… read more here.
Keywords: transporter; sultr2; chlamydomonas reinhardtii; accumulation ... See more keywords
Dopamine transporter binding in the brain is linked to irritable bowel syndrome in Parkinson's disease.
Sign Up to like & getrecommendations! Published in 2023 at "Brain and behavior"
DOI: 10.1002/brb3.3097
Abstract: BACKGROUND Gastrointestinal symptoms are common in Parkinson's disease (PD), but their neurophysiological correlates are not well understood. We recently reported that functional gastrointestinal symptoms were not associated with asymmetry per se but might be associated… read more here.
Keywords: dopamine transporter; gastrointestinal symptoms; transporter; parkinson disease ... See more keywords
Physiologically‐Based Pharmacokinetic Models for Evaluating Membrane Transporter Mediated Drug–Drug Interactions: Current Capabilities, Case Studies, Future Opportunities, and Recommendations
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Pharmacology and Therapeutics"
DOI: 10.1002/cpt.1693
Abstract: Physiologically‐based pharmacokinetic (PBPK) modeling has been extensively used to quantitatively translate in vitro data and evaluate temporal effects from drug–drug interactions (DDIs), arising due to reversible enzyme and transporter inhibition, irreversible time‐dependent inhibition, enzyme induction,… read more here.
Keywords: based pharmacokinetic; pbpk modeling; physiologically based; drug ... See more keywords
Regulation of Drug Transport Proteins—From Mechanisms to Clinical Impact: A White Paper on Behalf of the International Transporter Consortium
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Pharmacology and Therapeutics"
DOI: 10.1002/cpt.2605
Abstract: Membrane transport proteins are involved in the absorption, disposition, efficacy, and/or toxicity of many drugs. Numerous mechanisms (e.g., nuclear receptors, epigenetic gene regulation, microRNAs, alternative splicing, post‐translational modifications, and trafficking) regulate transport protein levels, localization,… read more here.
Keywords: disposition; transport proteins; transporter; transport ... See more keywords
New and Emerging Research on Solute Carrier and ATP Binding Cassette Transporters in Drug Discovery and Development: Outlook From the International Transporter Consortium
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Pharmacology and Therapeutics"
DOI: 10.1002/cpt.2627
Abstract: Enabled by a plethora of new technologies, research in membrane transporters has exploded in the past decade. The goal of this state‐of‐the‐art article is to describe recent advances in research on membrane transporters that are… read more here.
Keywords: discovery development; drug discovery; transporter; membrane transporters ... See more keywords
Organic Anion Transporter Gene Variants Associated With Plasma Exposure and Long‐Term Response to Atrasentan in Patients With Diabetic Kidney Disease
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DOI: 10.1002/cpt.2721
Abstract: Plasma exposure of the endothelin receptor antagonist atrasentan varies between individuals and is associated with nephroprotective effects and the risk of heart failure. We examined the influence of genetic polymorphisms on atrasentan plasma exposure and… read more here.
Keywords: atrasentan; kidney; plasma exposure; transporter ... See more keywords
Variants in Pharmacokinetic Transporters and Glycemic Response to Metformin: A Metgen Meta‐Analysis
Sign Up to like & getrecommendations! Published in 2017 at "Clinical Pharmacology and Therapeutics"
DOI: 10.1002/cpt.567
Abstract: Therapeutic response to metformin, a first‐line drug for type 2 diabetes (T2D), is highly variable, in part likely due to genetic factors. To date, metformin pharmacogenetic studies have mainly focused on the impact of variants… read more here.
Keywords: response metformin; response; analysis; metformin ... See more keywords
Active Pharmaceutical Ingredient Uptake by Zebrafish (Danio rerio) Oct2 (slc22a2) Transporter Expressed in Xenopus laevis Oocytes
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DOI: 10.1002/etc.5480
Abstract: Uptake of active pharmaceutical ingredients (APIs) across the gill epithelium of fish is via either a passive or facilitated transport process, with the latter being more important at the lower concentrations more readily observed in… read more here.
Keywords: oct2 slc22a2; toxicology; chemistry; transporter ... See more keywords
Novel role of the nociceptin system as a regulator of glutamate transporter expression in developing astrocytes
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DOI: 10.1002/glia.23210
Abstract: Our previous results showed that oligodendrocyte development is regulated by both nociceptin and its G‐protein coupled receptor, the nociceptin/orphanin FQ receptor (NOR). The present in vitro and in vivo findings show that nociceptin plays a… read more here.
Keywords: nociceptin; novel role; glutamate transporter; role ... See more keywords
Loss of glutamate transporter eaat2a leads to aberrant neuronal excitability, recurrent epileptic seizures, and basal hypoactivity
Sign Up to like & getrecommendations! Published in 2021 at "Glia"
DOI: 10.1002/glia.24106
Abstract: Astroglial excitatory amino acid transporter 2 (EAAT2, GLT‐1, and SLC1A2) regulates the duration and extent of neuronal excitation by removing glutamate from the synaptic cleft. Hence, an impairment in EAAT2 function could lead to an… read more here.
Keywords: excitability; epileptic seizures; glutamate; recurrent ... See more keywords