Use of a Caco-2 permeability assay to evaluate the effects of several Kampo medicines on the drug transporter P-glycoprotein
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DOI: 10.1007/s11418-018-1222-x
Abstract: In modern medical care in which Kampo and Western drugs are often combined, it is extremely important to clarify drug–drug interaction (DDI) to ensure safety and efficacy. However, there is little evidence of DDI in… read more here.
Keywords: five kampo; kampo medicines; drug; transporter glycoprotein ... See more keywords
The Differential Binding of Antipsychotic Drugs to the ABC Transporter P-Glycoprotein Predicts Cannabinoid–Antipsychotic Drug Interactions
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DOI: 10.1038/npp.2017.50
Abstract: Cannabis use increases rates of psychotic relapse and treatment failure in schizophrenia patients. Clinical studies suggest that cannabis use reduces the efficacy of antipsychotic drugs, but there has been no direct demonstration of this in… read more here.
Keywords: abc transporter; antipsychotic drug; transporter glycoprotein; risperidone ... See more keywords
The reliability of molecular dynamics simulations of the multidrug transporter P-glycoprotein in a membrane environment
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DOI: 10.1371/journal.pone.0191882
Abstract: Despite decades of research, the mechanism of action of the ABC multidrug transporter P-glycoprotein (P-gp) remains elusive. Due to experimental limitations, many researchers have turned to molecular dynamics simulation studies in order to investigate different… read more here.
Keywords: multidrug transporter; membrane environment; molecular dynamics; transporter glycoprotein ... See more keywords