Structural Aspects of Photopharmacology: Insight into the Binding of Photoswitchable and Photocaged Inhibitors to the Glutamate Transporter Homologue
Sign Up to like & getrecommendations! Published in 2021 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.0c11336
Abstract: Photopharmacology addresses the challenge of drug selectivity and side effects through creation of photoresponsive molecules activated with light with high spatiotemporal precision. This is achieved through incorporation of molecular photoswitches and photocages into the pharmacophore.… read more here.
Keywords: insight; transporter homologue; photopharmacology; glutamate transporter ... See more keywords
Structural ensemble of a glutamate transporter homologue in lipid nanodisc environment
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DOI: 10.1038/s41467-020-14834-8
Abstract: Glutamate transporters are cation-coupled secondary active membrane transporters that clear the neurotransmitter L-glutamate from the synaptic cleft. These transporters are homotrimers, with each protomer functioning independently by an elevator-type mechanism, in which a mobile transport… read more here.
Keywords: glutamate transporter; transporter homologue; glutamate; transport ... See more keywords