Introduction of scaffold nitrogen atoms renders inhibitors of the malarial L-lactate transporter, PfFNT, effective against the Gly107Ser resistance mutation.
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DOI: 10.1021/acs.jmedchem.0c00852
Abstract: The spreading of malaria parasites, Plasmodium falciparum, with resistance to all known drugs calls for novel classes of inhibitors with new modes of action. Recently, we discovered and validated the plasmodial L-lactate transporter, PfFNT, as… read more here.
Keywords: transporter pffnt; gly107ser; pffnt; lactate transporter ... See more keywords
Structural basis of transport and inhibition of the Plasmodium falciparum transporter PfFNT
Sign Up to like & getrecommendations! Published in 2021 at "EMBO reports"
DOI: 10.15252/embr.202153447
Abstract: In “Structural basis of transport and inhibition of the Plasmodium falciparum transporter PfFNT” by Lyu et al (2021), the authors depict the inhibitor MMV007839 in its hemiketal form in Fig 3A and F, Fig 4C,… read more here.
Keywords: structural basis; basis transport; transport inhibition; transporter pffnt ... See more keywords