Novel cerebrospinal fluid biomarkers of glucose transporter type 1 deficiency syndrome: Implications beyond the brain's energy deficit
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Inherited Metabolic Disease"
DOI: 10.1002/jimd.12554
Abstract: We used next‐generation metabolic screening to identify new biomarkers for improved diagnosis and pathophysiological understanding of glucose transporter type 1 deficiency syndrome (GLUT1DS), comparing metabolic cerebrospinal fluid (CSF) profiles from 12 patients to those of… read more here.
Keywords: deficiency syndrome; xylose; glucose transporter; transporter type ... See more keywords
Glucose transporter type 1 deficiency syndrome associated with autoantibodies to glutamate receptors
Sign Up to like & getrecommendations! Published in 2020 at "Brain and Development"
DOI: 10.1016/j.braindev.2020.05.010
Abstract: BACKGROUND The clinical spectrum of glucose transporter type 1 deficiency syndrome (GLUT1DS) has broadened, with increasing recognition of a milder phenotype. Antibodies targeting the subunits of glutamate receptors (GluRs), including GluN1, GluN2B, and GluD2, have… read more here.
Keywords: glucose transporter; deficiency syndrome; glutamate receptors; type deficiency ... See more keywords
Efficacy and safety of the glycine transporter type-1 inhibitor AMG 747 for the treatment of negative symptoms associated with schizophrenia
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DOI: 10.1016/j.schres.2016.10.027
Abstract: OBJECTIVE To determine the safety and efficacy of AMG 747, an oral inhibitor of glycine transporter type-1 (GlyT1), as an add-on to antipsychotic therapy in clinically stable people with schizophrenia with enduring negative symptoms. METHOD… read more here.
Keywords: glycine transporter; negative symptoms; treatment; amg 747 ... See more keywords
Sleep Disorder: An Overlooked Manifestation of Glucose Transporter Type-1 Deficiency Syndrome.
Sign Up to like & getrecommendations! Published in 2021 at "Neuropediatrics"
DOI: 10.1055/s-0041-1736179
Abstract: Glucose transporter type-1 deficiency syndrome (Glut1 DS) is a rare disorder with various manifestations. Early diagnosis is crucial because treatment with the ketogenic diet can lead to clinical improvement. Here, we report the cases of… read more here.
Keywords: glucose transporter; disorder; sleep disorder; deficiency syndrome ... See more keywords
One Molecule for Mental Nourishment and More: Glucose Transporter Type 1—Biology and Deficiency Syndrome
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DOI: 10.3390/biomedicines10061249
Abstract: Glucose transporter type 1 (Glut1) is the main transporter involved in the cellular uptake of glucose into many tissues, and is highly expressed in the brain and in erythrocytes. Glut1 deficiency syndrome is caused mainly… read more here.
Keywords: deficiency syndrome; glucose transporter; transporter type; transporter ... See more keywords
Chronic Hyperglycaemia Inhibits Tricarboxylic Acid Cycle in Rat Cardiomyoblasts Overexpressing Glucose Transporter Type 4
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23137255
Abstract: An oversupply of nutrients with a loss of metabolic flexibility and subsequent cardiac dysfunction are hallmarks of diabetic cardiomyopathy. Even if excess substrate is offered, the heart suffers energy depletion as metabolic fluxes are diminished.… read more here.
Keywords: rat cardiomyoblasts; cardiomyoblasts overexpressing; glucose transporter; transporter type ... See more keywords
High Estradiol Differentially Affects the Expression of the Glucose Transporter Type 4 in Pelvic Floor Muscles of Rats
Sign Up to like & getrecommendations! Published in 2018 at "International Neurourology Journal"
DOI: 10.5213/inj.1836116.058
Abstract: Purpose To characterize the relationship between serum estradiol levels and the expression of glucose transporter type 4 (Glut4) in the pubococcygeus and iliococcygeus muscles in female rats. Methods The muscles were excised from virgin rats… read more here.
Keywords: estradiol; muscle; glucose transporter; expression glucose ... See more keywords
Glucose transporter type 1 deficiency syndrome: clinical aspects, diagnosis, and treatment.
Sign Up to like & getrecommendations! Published in 2022 at "Archivos argentinos de pediatria"
DOI: 10.5546/aap.2022-02677.eng
Abstract: Glucose transporter type 1 deficiency with a typical onset is a genetic disorder associated with the SLC2A1 gene. Usually appears during the first years of life with severe developmental delay, drugresistant epilepsy, and movement disorders.… read more here.
Keywords: glucose transporter; deficiency syndrome; type deficiency; transporter type ... See more keywords