Integrative Data Mining, Scaffold Analysis, and Sequential Binary Classification Models for Exploring Ligand Profiles of Hepatic Organic Anion Transporting Polypeptides
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Chemical Information and Modeling"
DOI: 10.1021/acs.jcim.8b00466
Abstract: Hepatocellular organic anion transporting polypeptides (OATP1B1, OATP1B3, and OATP2B1) are important for proper liver function and the regulation of the drug elimination process. Understanding their roles in different conditions of liver toxicity and cancer requires… read more here.
Keywords: transporting polypeptides; anion transporting; sequential binary; organic anion ... See more keywords
Identification of novel cell-impermeant fluorescent substrates for testing the function and drug interaction of Organic Anion-Transporting Polypeptides, OATP1B1/1B3 and 2B1
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DOI: 10.1038/s41598-018-20815-1
Abstract: Organic Anion-Transporting Polypeptides are multispecific membrane proteins that regulate the passage of crucial endobiotics and drugs across pharmacological barriers. OATP1B1 and OATP1B3 have been described to play a major role in the hepatic uptake of… read more here.
Keywords: 1b3 2b1; oatp1b1 1b3; transporting polypeptides; anion transporting ... See more keywords