The Developmental Gene Hypothesis for Punctuated Equilibrium: Combined Roles of Developmental Regulatory Genes and Transposable Elements
Sign Up to like & getrecommendations! Published in 2020 at "BioEssays"
DOI: 10.1002/bies.201900173
Abstract: Theories of the genetics underlying punctuated equilibrium (PE) have been vague to date. Here the developmental gene hypothesis is proposed, which states that: 1) developmental regulatory (DevReg) genes are responsible for the orchestration of metazoan… read more here.
Keywords: developmental gene; gene hypothesis; developmental regulatory; hypothesis ... See more keywords
Reversing epigenetic repression of transposable elements for improving tumor immunogenicity
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DOI: 10.1002/cac2.12261
Abstract: In a recent study published in Nature, Zhang et al. [1] revealed a new epigenetic mechanism for restraining tumor intrinsic immunogenicity: Lysine demethylase 5B (KDM5B) recruits SET domain bifurcated histone lysine methyltransferase 1 (SETDB1) to… read more here.
Keywords: transposable elements; repression; immunogenicity; reversing epigenetic ... See more keywords
High genetic and epigenetic variation of transposable elements: Potential drivers to rapid adaptive evolution for the noxious invasive weed Mikania micrantha
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DOI: 10.1002/ece3.8075
Abstract: Abstract Why invasive species can rapidly adapt to novel environments is a puzzling question known as the genetic paradox of invasive species. This paradox is explainable in terms of transposable elements (TEs) activity, which are… read more here.
Keywords: variation; mikania micrantha; epigenetic variation; genetic epigenetic ... See more keywords
Transposable Elements.
Sign Up to like & getrecommendations! Published in 2019 at "Current topics in behavioral neurosciences"
DOI: 10.1007/7854_2019_112
Abstract: Transposable elements (TEs) are low-complexity elements (e.g., LINEs, SINEs, SVAs, and HERVs) that make up to two-thirds of the human genome. There is mounting evidence that TEs play an essential role in molecular functions that… read more here.
Keywords: transposable elements;
Identification of Active Transposable Elements in Plants: The Mobilome-Seq Approach.
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DOI: 10.1007/978-1-0716-1134-0_8
Abstract: Transposable elements (TEs) are the main component of eukaryotic genomes. Besides their impact on genome size, TEs are also functionally important as they can alter gene expression and influence phenotypic variation. In plants, most top-down… read more here.
Keywords: plants mobilome; identification active; active transposable; approach ... See more keywords
The genome of a thorny species: comparative genomic analysis among South and North American Cactaceae.
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DOI: 10.1007/s00425-021-03690-5
Abstract: MAIN CONCLUSION The first South American cactus nuclear genome assembly associated with comparative genomic analyses provides insights into nuclear and plastid genomic features, such as size, transposable elements, and metabolic processes related to cactus development.… read more here.
Keywords: genome thorny; cactaceae; fernambucensis; comparative genomic ... See more keywords
Genome-wide analysis of transposable elements in the coffee berry borer Hypothenemus hampei (Coleoptera: Curculionidae): description of novel families
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DOI: 10.1007/s00438-017-1291-7
Abstract: The coffee berry borer (CBB) Hypothenemus hampei is the most limiting pest of coffee production worldwide. The CBB genome has been recently sequenced; however, information regarding the presence and characteristics of transposable elements (TEs) was… read more here.
Keywords: coffee berry; hypothenemus hampei; berry borer; dna transposons ... See more keywords
Activation of transposable elements and genetic instability during long-term culture of the human fungal pathogen Candida albicans
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DOI: 10.1007/s10522-019-09809-2
Abstract: It has been repeatedly reported that transposable elements (TE) become active and/or mobile in the genomes of replicatively and stress-induced senescent mammalian cells. However, the biological role of senescence-associated transposon activation and its occurrence and… read more here.
Keywords: long term; candida albicans; culture; transposable elements ... See more keywords
Disrupting the disruptors: the consequences of mutations in mobile elements for ecologically important life history traits
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DOI: 10.1007/s10682-020-10038-0
Abstract: Transposable elements are a nearly ubiquitous component of eukaryotic genomes. While often described as parasitic genetic elements, other evidence suggests that transposable elements can become domesticated and contribute to organismal function. There is little empirical… read more here.
Keywords: life history; transposable elements; transposable element; ecology ... See more keywords
Tau Activates Transposable Elements in Alzheimer’s Disease
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DOI: 10.1016/j.celrep.2018.05.004
Abstract: SUMMARY Aging and neurodegenerative disease are characterized by genomic instability in neurons, including aberrant activation and mobilization of transposable elements (TEs). Integrating studies of human postmortem brain tissue and Drosophila melanogaster models, we investigate TE… read more here.
Keywords: tau; alzheimer disease; tau activates; activation ... See more keywords
Transposable element dysregulation in systemic lupus erythematosus and regulation by histone conformation and Hsp90.
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DOI: 10.1016/j.clim.2018.08.011
Abstract: Systemic lupus erythematosus (SLE) represents an autoimmune disease in which activation of the type I interferon pathway leads to dysregulation of tolerance and the generation of autoantibodies directed against nuclear constituents. The mechanisms driving the… read more here.
Keywords: transposable element; systemic lupus; dysregulation; expression ... See more keywords