Association of Low Plasma Transthyretin Concentration With Risk of Heart Failure in the General Population.
Sign Up to like & getrecommendations! Published in 2020 at "JAMA cardiology"
DOI: 10.1001/jamacardio.2020.5969
Abstract: Importance Several lines of evidence support low plasma transthyretin concentration as an in vivo biomarker of transthyretin tetramer instability, a prerequisite for the development of both wild-type transthyretin cardiac amyloidosis (ATTRwt) and hereditary transthyretin cardiac… read more here.
Keywords: general population; plasma transthyretin; transthyretin concentration; concentration ... See more keywords
Advances in the treatment of hereditary transthyretin amyloidosis: A review
Sign Up to like & getrecommendations! Published in 2019 at "Brain and Behavior"
DOI: 10.1002/brb3.1371
Abstract: Amyloid transthyretin amyloidosis (ATTR) is a progressive and often fatal disease caused by the buildup of mutated (hereditary ATTR [hATTR]; also known as ATTR variant [ATTRv]) or normal transthyretin (wild‐type ATTR) throughout the body. Two… read more here.
Keywords: transthyretin amyloidosis; amyloidosis; advances treatment; attr ... See more keywords
Trajectory of left ventricular geometry and diastolic dysfunction in hereditary transthyretin cardiac amyloidosis
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DOI: 10.1002/ehf2.13454
Abstract: Amyloid transthyretin (ATTR) depositions cause left ventricular (LV) hypertrophy, diastolic dysfunction, and heart failure. The time course of changes in LV geometry and diastolic dysfunction has not been fully reported in patients with ATTR cardiomyopathy.… read more here.
Keywords: geometry diastolic; left ventricular; geometry; diastolic dysfunction ... See more keywords
Time to reconsider thromboembolic risk and anticoagulation in transthyretin cardiac amyloidosis?
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Heart Failure"
DOI: 10.1002/ejhf.2648
Abstract: This article refers to ‘Systemic embolism in amyloid transthyretin cardiomyopathy’ by S. Vilches et al. , pub-lished in Eur J Heart Fail 2022;24: 1 387– 1 396. read more here.
Keywords: time reconsider; transthyretin; thromboembolic risk; anticoagulation transthyretin ... See more keywords
Cellular secretion and cytotoxicity of transthyretin mutant proteins underlie late-onset amyloidosis and neurodegeneration
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DOI: 10.1007/s00018-019-03357-1
Abstract: Transthyretin amyloidosis (ATTR) is a progressive life-threatening disease characterized by the deposition of transthyretin (TTR) amyloid fibrils. Several pathogenic variants have been shown to destabilize TTR tetramers, leading to aggregation of misfolded TTR fibrils. However,… read more here.
Keywords: late onset; ttr; amyloidosis; underlie late ... See more keywords
Diagnostic accuracy of bone scintigraphy in the assessment of cardiac transthyretin-related amyloidosis: a bivariate meta-analysis
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Nuclear Medicine and Molecular Imaging"
DOI: 10.1007/s00259-018-4013-4
Abstract: PurposeCardiac transthyretin-related amyloidosis (ATTR) is a progressive and fatal cardiomyopathy. The diagnosis of this disease is frequently delayed or missed due to the limited specificity of echocardiography. An increasing amount of data in the literature… read more here.
Keywords: bone scintigraphy; scintigraphy; diagnostic accuracy; bone ... See more keywords
Molecular dynamics simulation study of AG10 and tafamidis binding to the Val122Ile transthyretin variant
Sign Up to like & getrecommendations! Published in 2020 at "Biochemistry and Biophysics Reports"
DOI: 10.1016/j.bbrep.2019.100721
Abstract: Molecular dynamics (MD) simulations were used to investigate the binding of four ligands to the Val122Ile mutant of the protein transthyretin. Dissociation, misfolding, and subsequent aggregation of mutated transthyretin proteins are associated with the disease… read more here.
Keywords: molecular dynamics; simulation study; two point; simulation ... See more keywords
Transthyretin Cardiac Amyloidosis in the Black Population: A Ten-Year Experience
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cardiac Failure"
DOI: 10.1016/j.cardfail.2019.07.023
Abstract: Introduction Transthyretin (ATTR) cardiac amyloidosis (CA) is becoming increasingly recognized as an underlying pathology of heart failure with preserved ejection fraction (HFpEF) in elderly patients. One in 25 African Americans are carriers of the hereditary… read more here.
Keywords: 122 ile; population; transthyretin; cardiac amyloidosis ... See more keywords
Mitra-clip in Transthyretin Amyloidosis Cardiomyopathy A Case Series
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cardiac Failure"
DOI: 10.1016/j.cardfail.2020.09.464
Abstract: Introduction Non-invasive valvular interventions have dramatically changed the management of patients with multiple complex comorbidities. Patients with cardiac amyloidosis (CA) are often considered high-risk for surgical intervention. Trans-catheter aortic valve replacement (TAVR) is tolerated in… read more here.
Keywords: mitraclip; dyspnea; mitral valve; amyloidosis ... See more keywords
Is transthyretin a good marker of nutritional status?
Sign Up to like & getrecommendations! Published in 2017 at "Clinical nutrition"
DOI: 10.1016/j.clnu.2016.06.004
Abstract: The assay of plasma transthyretin (TTR), also known as prealbumin, is a key step in the assessment of nutritional status. However, it remains unclear whether it really is a useful nutrition marker, and when and… read more here.
Keywords: malnutrition; ttr; nutritional status; good marker ... See more keywords
Assessment of transthyretin cut-off values for a better screening of malnutrition: Retrospective determination and prospective validation.
Sign Up to like & getrecommendations! Published in 2020 at "Clinical nutrition"
DOI: 10.1016/j.clnu.2020.06.017
Abstract: The use of transthyretin (TTR, prealbumin) as a marker of malnutrition and the definition of associated cut-offs are a matter of debate. In order to clarify this issue, we performed a retrospective study and then… read more here.
Keywords: malnutrition; prospective validation; cut; cut values ... See more keywords