Development of a Highly Potent Transthyretin Amyloidogenesis Inhibitor: Design, Synthesis, and Evaluation
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DOI: 10.1021/acs.jmedchem.2c01195
Abstract: Transthyretin amyloidosis (ATTR) is a group of fatal diseases described by the misfolding and amyloid deposition of transthyretin (TTR). Discovering small molecules that bind and stabilize the TTR tetramer, preventing its dissociation and subsequent aggregation,… read more here.
Keywords: highly potent; development highly; design; transthyretin amyloidogenesis ... See more keywords
Review on the Structures and Activities of Transthyretin Amyloidogenesis Inhibitors
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DOI: 10.2147/dddt.s237252
Abstract: Abstract Transthyretin (TTR) is a tetrameric protein, and its dissociation, aggregation, deposition, and misfolding are linked to several human amyloid diseases. As the main transporter for thyroxine (T4) in plasma and cerebrospinal fluid, TTR contains… read more here.
Keywords: structures activities; activities transthyretin; ttr; transthyretin amyloidogenesis ... See more keywords
Santalol Isomers Inhibit Transthyretin Amyloidogenesis and Associated Pathologies in Caenorhabditis elegans
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.924862
Abstract: Transthyretin (TTR) is a homotetrameric protein found in human serum and is implicated in fatal inherited amyloidoses. Destabilization of native TTR confirmation resulting from mutation, environmental changes, and aging causes polymerization and amyloid fibril formation.… read more here.
Keywords: inhibit transthyretin; ttr; amyloidogenesis associated; isomers inhibit ... See more keywords