Ser77Tyr transthyretin amyloidosis in Israel: Initial manifestations and diagnostic features
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DOI: 10.1002/acn3.51741
Abstract: Amyloidosis due to the transthyretin Ser77Tyr mutation (ATTRS77Y) is a rare autosomal‐dominant disorder, characterized by carpal‐tunnel syndrome, poly‐ and autonomic‐neuropathy, and cardiomyopathy. However, related symptoms and signs are often nonspecific and confirmatory tests are required.… read more here.
Keywords: diagnostic features; israel initial; ser77tyr transthyretin; amyloidosis israel ... See more keywords
Novel screening for transthyretin amyloidosis by using fat ultrasonography
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DOI: 10.1002/ana.24914
Abstract: We aimed to assess the possibility of using a noninvasive screening method for hereditary transthyretin amyloidosis by means of abdominal fat ultrasonography. Quantitative analysis of ultrasound B‐mode images demonstrated a significant increase in mean echogenicity… read more here.
Keywords: novel screening; transthyretin amyloidosis; amyloidosis; hereditary transthyretin ... See more keywords
Advances in the treatment of hereditary transthyretin amyloidosis: A review
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DOI: 10.1002/brb3.1371
Abstract: Amyloid transthyretin amyloidosis (ATTR) is a progressive and often fatal disease caused by the buildup of mutated (hereditary ATTR [hATTR]; also known as ATTR variant [ATTRv]) or normal transthyretin (wild‐type ATTR) throughout the body. Two… read more here.
Keywords: transthyretin amyloidosis; amyloidosis; advances treatment; attr ... See more keywords
Transthyretin amyloidosis: the picture is getting clearer
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DOI: 10.1002/ejhf.2641
Abstract: This article refers to ‘Prevalence and clinical outcomes of transthyretin amyloidosis: a systematic review and meta-analysis’ by A.S. Antonopoulos et al. , published in this issue on pages 1 677– 1 696. read more here.
Keywords: picture getting; getting clearer; amyloidosis picture; transthyretin amyloidosis ... See more keywords
Frequency of hereditary transthyretin amyloidosis among elderly patients with transthyretin cardiomyopathy
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DOI: 10.1002/ejhf.2658
Abstract: Transthyretin amyloid cardiomyopathy (ATTR‐CM) is increasingly recognized as a cause of heart failure in the elderly. Although wild‐type transthyretin amyloidosis is the most frequent form of ATTR‐CM found in the elderly, hereditary transthyretin amyloidosis (ATTRv)… read more here.
Keywords: frequency hereditary; amyloidosis among; hereditary transthyretin; transthyretin amyloidosis ... See more keywords
Chance or challenge, spoilt for choice? New recommendations on diagnostic and therapeutic considerations in hereditary transthyretin amyloidosis with polyneuropathy: the German/Austrian position and review of the literature
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DOI: 10.1007/s00415-020-09962-6
Abstract: Hereditary transthyretin amyloidosis is caused by pathogenic variants (ATTR v ) in the TTR gene. Alongside cardiac dysfunction, the disease typically manifests with a severely progressive sensorimotor and autonomic polyneuropathy. Three different drugs, tafamidis, patisiran,… read more here.
Keywords: recommendations diagnostic; transthyretin amyloidosis; diagnostic therapeutic; amyloidosis ... See more keywords
Advances in the diagnosis and treatment of transthyretin amyloidosis with cardiac involvement
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DOI: 10.1007/s10741-019-09776-3
Abstract: Amyloidosis is caused by extracellular deposition of insoluble abnormal fibrils constituted by misfolded proteins, which can modify tissue anatomy and hinder the function of multiple organs including the heart. Amyloidosis that can affect the heart… read more here.
Keywords: diagnosis; diagnosis treatment; transthyretin amyloidosis; amyloidosis cardiac ... See more keywords
Emerging Therapies for Transthyretin Cardiac Amyloidosis
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DOI: 10.1007/s11936-019-0743-2
Abstract: Transthyretin cardiac amyloidosis is an underdiagnosed, undertreated disease which is associated with significant morbidity and mortality. This review will discuss the recent advancements in novel therapies for transthyretin amyloidosis. In recent phase 3 clinical trials,… read more here.
Keywords: transthyretin amyloidosis; therapies transthyretin; amyloidosis; emerging therapies ... See more keywords
Prognostic significance of incidental suspected transthyretin amyloidosis on routine bone scintigraphy
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DOI: 10.1007/s12350-020-02396-7
Abstract: Transthyretin amyloidosis (ATTR) is an occasional incidental finding on bone scintigraphy. We studied its prognostic impact in elderly patients. The study population consisted of 2000 patients aged over 70 years who underwent bone scintigraphies with… read more here.
Keywords: cardiovascular mortality; bone scintigraphy; transthyretin amyloidosis; bone ... See more keywords
Evaluation of Mortality During Long-Term Treatment with Tafamidis for Transthyretin Amyloidosis with Polyneuropathy: Clinical Trial Results up to 8.5 Years
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DOI: 10.1007/s40120-020-00180-w
Abstract: Introduction The effects of tafamidis on mortality in Val30Met and non-Val30Met patients with transthyretin amyloidosis with polyneuropathy (ATTR-PN) were evaluated. Methods The analyses were based on cumulative data from the Val30Met patients in the 18-month… read more here.
Keywords: long term; transthyretin amyloidosis; treatment; mortality ... See more keywords
Angiographic Signatures of the Predominant Form of Familial Transthyretin Amyloidosis (Val30Met Mutation).
Sign Up to like & getrecommendations! Published in 2018 at "American journal of ophthalmology"
DOI: 10.1016/j.ajo.2018.05.023
Abstract: PURPOSE To describe abnormalities in choroidal and retinal vasculature associated with Val30Met familial transthyretin amyloidosis (V30M-FTA) using fluorescein and indocyanine green (ICG) angiography. DESIGN Prospective, cross-sectional study. METHODS This study was conducted at the French… read more here.
Keywords: familial transthyretin; v30m fta; transthyretin amyloidosis;