[Gene therapy options for hereditary transthyretin-related amyloidosis].
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DOI: 10.1007/s00115-022-01288-0
Abstract: Hereditary transthyretin-related amyloidosis (ATTRv) is a rare autosomal dominant disease and is fatal if left untreated. It is caused by mutations in the transthyretin gene. All known mutations induce misfolding of the tetrameric transthyretin molecule and… read more here.
Keywords: treatment; transthyretin related; hereditary transthyretin; gene ... See more keywords
6-OHDA-induced dopaminergic neurodegeneration in Caenorhabditis elegans is promoted by the engulfment pathway and inhibited by the transthyretin-related protein TTR-33
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DOI: 10.1371/journal.pgen.1007125
Abstract: Oxidative stress is linked to many pathological conditions including the loss of dopaminergic neurons in Parkinson’s disease. The vast majority of disease cases appear to be caused by a combination of genetic mutations and environmental… read more here.
Keywords: protein; transthyretin related; ttr; dopaminergic neurons ... See more keywords
Risk stratification in transthyretin-related cardiac amyloidosis
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DOI: 10.3389/fcvm.2023.1151803
Abstract: Transthyretin related cardiac amyloidosis (TTR-CA) is an infiltrative cardiomyopathy that cause heart failure with preserved ejection fraction, mainly in aging people. Due to the introduction of a non invasive diagnostic algorithm, this disease, previously considered… read more here.
Keywords: transthyretin related; cardiac amyloidosis; risk stratification; related cardiac ... See more keywords