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Published in 2020 at "Mitochondrion"
DOI: 10.1016/j.mito.2020.08.001
Abstract: Mitochondria play a central role in regulating cellular energy metabolism. However, the present understanding of mitochondria has changed from its unipotent functions to pluripotent and insists on understanding the role of mitochondria not only in…
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Keywords:
mitochondrial chaperone;
trap1 cells;
metastasis;
chaperone trap1 ... See more keywords
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Published in 2021 at "Trends in pharmacological sciences"
DOI: 10.1016/j.tips.2021.04.003
Abstract: TRAP1, the mitochondrial isoform of heat shock protein (Hsp)90 chaperones, is a key regulator of metabolism and organelle homeostasis in diverse pathological states. While selective TRAP1 targeting is an attractive goal, classical active-site-directed strategies have…
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Keywords:
mitochondrial chaperone;
strategies therapeutic;
trap1 strategies;
chaperone trap1 ... See more keywords
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Published in 2018 at "Journal of chemical theory and computation"
DOI: 10.1021/acs.jctc.7b00766
Abstract: The Hsp90 family of molecular chaperones oversees the folding of a wide range of client proteins. Hsp90 is a homodimer, whose conformational states and functions are regulated by ATP-binding and hydrolysis. The crystal structure of…
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Keywords:
asymmetry;
hydrolysis;
structural asymmetry;
trap1 ... See more keywords
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Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-273
Abstract: Tumor necrosis factor receptor-associated protein 1 (TRAP1) is a mitochondrial homolog of HSP90 chaperones. It plays an important role in protection against oxidative stress and apoptosis by regulating reactive oxidative species (ROS). Recent studies have…
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Keywords:
depletion;
inhibitor;
trap1;
colon cancer ... See more keywords
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Published in 2022 at "Biomolecules"
DOI: 10.3390/biom12060786
Abstract: Mitochondrial function is dependent on molecular chaperones, primarily due to their necessity in the formation of respiratory complexes and clearance of misfolded proteins. Heat shock proteins (Hsps) are a subset of molecular chaperones that function…
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Keywords:
metabolic switch;
chaperones metabolic;
switch cancer;
trap1 ... See more keywords
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Published in 2022 at "International Journal of Oncology"
DOI: 10.3892/ijo.2022.5369
Abstract: Metabolic rewiring fuels rapid cancer cell proliferation by promoting adjustments in energetic resources, and increasing glucose uptake and its conversion into lactate, even in the presence of oxygen. Furthermore, solid tumors often contain hypoxic areas…
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Keywords:
cancer cells;
trap1;
colorectal cancer;
oxygen deprivation ... See more keywords