Targeting the mitochondrial chaperone TRAP1: strategies and therapeutic perspectives.
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DOI: 10.1016/j.tips.2021.04.003
Abstract: TRAP1, the mitochondrial isoform of heat shock protein (Hsp)90 chaperones, is a key regulator of metabolism and organelle homeostasis in diverse pathological states. While selective TRAP1 targeting is an attractive goal, classical active-site-directed strategies have… read more here.
Keywords: mitochondrial chaperone; strategies therapeutic; trap1 strategies; chaperone trap1 ... See more keywords