The TRAPP complexes: oligomeric exchange factors that activate the small GTPases Rab1 and Rab11
Sign Up to like & getrecommendations! Published in 2022 at "Febs Letters"
DOI: 10.1002/1873-3468.14553
Abstract: The Transport Protein Particle (TRAPP) complexes are highly conserved multisubunit complexes that act as nucleotide exchange factors (GEFs) for Rab GTPases. They act in both protein secretion and autophagy and have also been proposed to… read more here.
Keywords: trapp complexes; complexes oligomeric; oligomeric exchange; exchange factors ... See more keywords
Druggability Assessment in TRAPP Using Machine Learning Approaches
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DOI: 10.1021/acs.jcim.9b01185
Abstract: Accurate protein druggability predictions are important for the selection of drug targets in the early stages of drug discovery. Due to the flexible nature of proteins, the druggability of a binding pocket may vary due… read more here.
Keywords: trapp; binding pocket; trapp using; druggability ... See more keywords
Biallelic variants in TRAPPC10 cause a microcephalic TRAPPopathy disorder in humans and mice
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DOI: 10.1371/journal.pgen.1010114
Abstract: The highly evolutionarily conserved transport protein particle (TRAPP) complexes (TRAPP II and III) perform fundamental roles in subcellular trafficking pathways. Here we identified biallelic variants in TRAPPC10, a component of the TRAPP II complex, in… read more here.
Keywords: humans mice; trappc10; biallelic variants; variants trappc10 ... See more keywords