The Potency of Diarylamine Radical-Trapping Antioxidants as Inhibitors of Ferroptosis Underscores the Role of Autoxidation in the Mechanism of Cell Death.
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DOI: 10.1021/acschembio.7b00730
Abstract: Two aromatic amines (ferrostatin-1 and liproxstatin-1) were recently identified from high-throughput screening efforts to uncover potent inhibitors of ferroptosis, the necrotic-like cell death induced by inhibition of glutathione peroxidase 4 (GPX4), deletion of the corresponding… read more here.
Keywords: inhibitors ferroptosis; autoxidation; radical trapping; trapping antioxidants ... See more keywords