Caveolin-1 mediates cellular distribution of HER2 and affects trastuzumab binding and therapeutic efficacy
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DOI: 10.1038/s41467-018-07608-w
Abstract: Human epidermal growth factor receptor 2 (HER2) gene amplification and/or protein overexpression in tumors is a prerequisite for initiation of trastuzumab therapy. Although HER2 is a cell membrane receptor, differential rates of endocytosis and recycling… read more here.
Keywords: trastuzumab binding; cell membrane; her2 cell; cav1 ... See more keywords