Patient-reported function, health-related quality of life, and symptoms in APHINITY: pertuzumab plus trastuzumab and chemotherapy in HER2-positive early breast cancer.
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DOI: 10.1038/s41416-021-01323-y
Abstract: BACKGROUND We assessed health-related quality of life (symptoms of therapy/patient functioning/global health status), in APHINITY (pertuzumab/placebo, trastuzumab, and chemotherapy as adjuvant HER2-positive early breast cancer therapy). METHODS Patients received 1 year/18 cycles of pertuzumab/placebo with… read more here.
Keywords: chemotherapy; trastuzumab chemotherapy; health related; cancer ... See more keywords
The KEYNOTE-811 trial of dual PD-1 and HER2 blockade in HER2-positive gastric cancer.
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DOI: 10.1038/s41586-021-04161-3
Abstract: Human epidermal growth factor receptor 2 (HER2, also known as ERBB2) amplification or overexpression occurs in approximately 20% of advanced gastric or gastro-oesophageal junction adenocarcinomas1-3. More than a decade ago, combination therapy with the anti-HER2 antibody… read more here.
Keywords: keynote 811; positive gastric; her2; her2 positive ... See more keywords
First-line pembrolizumab/placebo plus trastuzumab and chemotherapy in HER2-positive advanced gastric cancer: KEYNOTE-811
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DOI: 10.2217/fon-2020-0737
Abstract: Treatment options for patients with HER2-positive advanced gastric cancer are limited, and the prognosis for these patients is poor. Pembrolizumab has demonstrated promising antitumor activity in patients with advanced gastric or gastroesophageal junction adenocarcinoma as… read more here.
Keywords: chemotherapy; advanced gastric; her2 positive; gastric cancer ... See more keywords
Estudio en vida real de pertuzumab-trastuzumabquimioterapia frente a trastuzumab-quimioterapia en neoadyuvancia en cáncer de mama
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DOI: 10.7399/fh.11376
Abstract: Objective: The primary objective of the study is to compare the effectiveness of trastuzumab-chemotherapy with and without pertuzumab. As a secondary objective, we seek to evaluate the cardiac safety of the treatment. Method: Retrospective observational study including all… read more here.
Keywords: complete pathological; pertuzumab; trastuzumab chemotherapy; cardiac safety ... See more keywords