Impacts of non-recovery of trastuzumab-induced cardiomyopathy on clinical outcomes in patients with breast cancer
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Research in Cardiology"
DOI: 10.1007/s00392-019-01417-x
Abstract: ObjectivesThe impacts of non-recovery of trastuzumab-induced left ventricular dysfunction (LVD) on clinical outcomes in breast cancer have been poorly studied. We investigated the predictors of LV-functional non-recovery and its impacts on clinical outcomes in breast… read more here.
Keywords: lvd group; non recovery; recovered lvd; trastuzumab induced ... See more keywords
Prediction of trastuzumab-induced cardiotoxicity in breast cancer patients receiving anthracycline-based chemotherapy
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Echocardiography"
DOI: 10.1007/s12574-018-0394-4
Abstract: BackgroundAdjuvant trastuzumab improved overall survival and reduced the risk for disease recurrence in women with breast cancers, because of its potential cardiotoxicity, careful monitoring of left ventricular (LV) function during treatment is required.MethodsThis study investigates,… read more here.
Keywords: cancer patients; trastuzumab induced; breast; breast cancer ... See more keywords
PTX3 from vascular endothelial cells contributes to trastuzumab-induced cardiac complications
Sign Up to like & getrecommendations! Published in 2023 at "Cardiovascular Research"
DOI: 10.1093/cvr/cvad012
Abstract: Abstract Aims Trastuzumab, the first humanized monoclonal antibody that targets human epidermal growth factor receptor 2 (ERBB2/HER2), is currently used as a first-line treatment for HER2 (+) tumours. However, trastuzumab increases the risk of cardiac… read more here.
Keywords: trastuzumab induced; cardiac complications; endothelial cells; ptx3 ... See more keywords
Trastuzumab induced negative chronotropic and lusitropic effects in cynomolgus monkeys.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of cardiovascular pharmacology"
DOI: 10.1097/fjc.0000000000001157
Abstract: ABSTRACT Treatment with trastuzumab, an anti-human epidermal growth factor receptor type 2 humanized monoclonal antibody, has been associated with heart failure in certain cancer patients; however, the mechanism underlying trastuzumab-induced cardiac dysfunction remains unclear. The… read more here.
Keywords: cynomolgus monkeys; negative chronotropic; trastuzumab; trastuzumab induced ... See more keywords
Trastuzumab-induced cardiotoxicity in early breast cancer over a 10-year period in Uruguay
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DOI: 10.1097/md.0000000000029927
Abstract: This srudy aimed to estimate the prevalence of trastuzumab-induced cardiotoxicity in Uruguayan women diagnosed with human epidermal growth factor receptor 2 (HER2)-positive breast cancer over a 10-year period, who were treated under the financial coverage… read more here.
Keywords: breast cancer; trastuzumab induced; cardiotoxicity;
Anthracycline and trastuzumab-induced cardiotoxicity in breast cancer.
Sign Up to like & getrecommendations! Published in 2018 at "European review for medical and pharmacological sciences"
DOI: 10.26355/eurrev_201804_14752
Abstract: OBJECTIVE Breast cancer is the most common cancer among women. In the last twenty years early diagnosis, neoadjuvant and adjuvant systemic treatment that targeted to specific molecular targets have significantly reduced the mortality from breast… read more here.
Keywords: anthracycline trastuzumab; trastuzumab induced; breast cancer; cardiotoxicity ... See more keywords
The Research Progress of Trastuzumab-Induced Cardiotoxicity in HER-2-Positive Breast Cancer Treatment
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2021.821663
Abstract: In recent years, the incidence of breast cancer has been increasing on an annual basis. Human epidermal growth factor receptor-2 (HER-2) is overexpressed in 15-20% human breast cancers, which is associated with poor prognosis and… read more here.
Keywords: induced cardiotoxicity; trastuzumab induced; cardiotoxicity; breast cancer ... See more keywords
Biomarker panel for early screening of trastuzumab -induced cardiotoxicity among breast cancer patients in west virginia
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.953178
Abstract: Cardiotoxicity is a well-known pathophysiological consequence in breast cancer patients receiving trastuzumab. Trastuzumab related cardiotoxicity typically results in an overall decline in cardiac function, primarily characterized by reduction in left ventricular ejection fraction (LVEF) and… read more here.
Keywords: trastuzumab induced; cancer patients; cardiotoxicity; breast cancer ... See more keywords