Articles with "trastuzumab resistant" as a keyword



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TRAIL receptor activation overcomes resistance to trastuzumab in HER2 positive breast cancer cells.

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Published in 2019 at "Cancer letters"

DOI: 10.1016/j.canlet.2019.03.042

Abstract: The appearance of resistance to the anti-HER2 targeted drug trastuzumab constitutes, nowadays, an important challenge in the oncology clinic. To fight such resistance, we searched for potential vulnerabilities in cells resistant to that drug. To… read more here.

Keywords: her2 positive; trastuzumab resistant; trastuzumab; resistance ... See more keywords
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JWA suppresses proliferation in trastuzumab-resistant breast cancer by downregulating CDK12

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Published in 2021 at "Cell Death Discovery"

DOI: 10.1038/s41420-021-00693-9

Abstract: Breast cancer is the most common cancer worldwide. JWA is a microtubule-associated protein that has been identified as a tumor suppressor, and its downregulation in tumors is an independent adverse prognostic factor. The objective of… read more here.

Keywords: breast; trastuzumab resistant; resistant breast; jwa ... See more keywords
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Nectin-4 cis-interacts with ErbB2 and its trastuzumab-resistant splice variants, enhancing their activation and DNA synthesis

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Published in 2019 at "Scientific Reports"

DOI: 10.1038/s41598-019-55460-9

Abstract: Nectin-4 cell adhesion molecule and ErbB2 tyrosine kinase receptor are upregulated in many cancers, including breast cancer, and promote cancer cell proliferation and metastasis. Using human breast cancer cell lines T47D and SUM190-PT, in which… read more here.

Keywords: trastuzumab resistant; splice variants; nectin cis; activation ... See more keywords
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Bioinformatics Analysis of Potential Key Genes in Trastuzumab-Resistant Gastric Cancer

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Published in 2019 at "Disease Markers"

DOI: 10.1155/2019/1372571

Abstract: Background This study was performed to identify genes related to acquired trastuzumab resistance in gastric cancer (GC) and to analyze their prognostic value. Methods The gene expression profile GSE77346 was downloaded from the Gene Expression… read more here.

Keywords: resistant gastric; trastuzumab resistant; gastric cancer; hub genes ... See more keywords
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Abstract 1831: PKCδ as a novel target for HER2-positive, trastuzumab resistant breast cancer

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Published in 2018 at "Cancer Research"

DOI: 10.1158/1538-7445.am2018-1831

Abstract: Breast cancer is the most common cancer diagnosis and second leading cause of cancer related deaths among women in the United States. This poor prognosis is in part due to the high rates of resistance.… read more here.

Keywords: cancer; pkc; trastuzumab resistant; breast cancer ... See more keywords
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ESE-1 Knockdown Attenuates Growth in Trastuzumab-resistant HER2+ Breast Cancer Cells.

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Published in 2017 at "Anticancer research"

DOI: 10.21873/anticanres.12115

Abstract: BACKGROUND/AIM ESE-1/Elf3 controls transformation properties in mammary epithelial cells, and is most clinically relevant in HER2+ breast cancer. Herein we showed that ESE-1 knockdown inhibits tumorigenic growth in HER2+, trastuzumab-resistant HR20 (derived from HER2+ ER+… read more here.

Keywords: her2 breast; ese knockdown; trastuzumab resistant; breast cancer ... See more keywords