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Published in 2019 at "Cancer letters"
DOI: 10.1016/j.canlet.2019.03.042
Abstract: The appearance of resistance to the anti-HER2 targeted drug trastuzumab constitutes, nowadays, an important challenge in the oncology clinic. To fight such resistance, we searched for potential vulnerabilities in cells resistant to that drug. To…
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Keywords:
her2 positive;
trastuzumab resistant;
trastuzumab;
resistance ... See more keywords
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Published in 2021 at "Cell Death Discovery"
DOI: 10.1038/s41420-021-00693-9
Abstract: Breast cancer is the most common cancer worldwide. JWA is a microtubule-associated protein that has been identified as a tumor suppressor, and its downregulation in tumors is an independent adverse prognostic factor. The objective of…
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Keywords:
breast;
trastuzumab resistant;
resistant breast;
jwa ... See more keywords
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Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-55460-9
Abstract: Nectin-4 cell adhesion molecule and ErbB2 tyrosine kinase receptor are upregulated in many cancers, including breast cancer, and promote cancer cell proliferation and metastasis. Using human breast cancer cell lines T47D and SUM190-PT, in which…
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Keywords:
trastuzumab resistant;
splice variants;
nectin cis;
activation ... See more keywords
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Published in 2019 at "Disease Markers"
DOI: 10.1155/2019/1372571
Abstract: Background This study was performed to identify genes related to acquired trastuzumab resistance in gastric cancer (GC) and to analyze their prognostic value. Methods The gene expression profile GSE77346 was downloaded from the Gene Expression…
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Keywords:
resistant gastric;
trastuzumab resistant;
gastric cancer;
hub genes ... See more keywords
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Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-1831
Abstract: Breast cancer is the most common cancer diagnosis and second leading cause of cancer related deaths among women in the United States. This poor prognosis is in part due to the high rates of resistance.…
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Keywords:
cancer;
pkc;
trastuzumab resistant;
breast cancer ... See more keywords
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Published in 2017 at "Anticancer research"
DOI: 10.21873/anticanres.12115
Abstract: BACKGROUND/AIM ESE-1/Elf3 controls transformation properties in mammary epithelial cells, and is most clinically relevant in HER2+ breast cancer. Herein we showed that ESE-1 knockdown inhibits tumorigenic growth in HER2+, trastuzumab-resistant HR20 (derived from HER2+ ER+…
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Keywords:
her2 breast;
ese knockdown;
trastuzumab resistant;
breast cancer ... See more keywords