Trauma-Induced Nanohydroxyapatite Deposition in Skeletal Muscle is Sufficient to Drive Heterotopic Ossification
Sign Up to like & getrecommendations! Published in 2018 at "Calcified Tissue International"
DOI: 10.1007/s00223-018-0502-5
Abstract: Heterotopic ossification (HO), or the pathologic formation of bone within soft tissues, is a significant complication following severe injuries as it impairs joint motion and function leading to loss of the ability to perform activities… read more here.
Keywords: skeletal muscle; heterotopic ossification; muscle; deposition ... See more keywords
A CRHR1 antagonist prevents synaptic loss and memory deficits in a trauma-induced delirium-like syndrome
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Psychiatry"
DOI: 10.1038/s41380-020-0659-y
Abstract: Older patients with severe physical trauma are at high risk of developing neuropsychiatric syndromes with global impairment of cognition, attention, and consciousness. We employed a thoracic trauma (TxT) mouse model and thoroughly analyzed age-dependent spatial… read more here.
Keywords: synaptic loss; trauma induced; crhr1 antagonist; induced delirium ... See more keywords
Trauma-induced coagulopathy
Sign Up to like & getrecommendations! Published in 2021 at "Nature Reviews Disease Primers"
DOI: 10.1038/s41572-021-00270-5
Abstract: This PrimeView highlights the complex interactions between both prothrombotic and antithrombotic mechanisms that underlie trauma-induced coagulopathy. read more here.
Keywords: induced coagulopathy; trauma induced;
Alternative blood products in trauma
Sign Up to like & getrecommendations! Published in 2022 at "Current Opinion in Anaesthesiology"
DOI: 10.1097/aco.0000000000001217
Abstract: Purpose of review Hemorrhage and trauma-induced coagulopathy cause significant morbidity and mortality in trauma patients. Although blood products are the cornerstone of resuscitation, these resources are scarce, necessitating alternatives. This review examines the use of… read more here.
Keywords: trauma induced; products trauma; blood products; alternative blood ... See more keywords
Early haemorrhage control and management of trauma-induced coagulopathy: the importance of goal-directed therapy
Sign Up to like & getrecommendations! Published in 2017 at "Current Opinion in Critical Care"
DOI: 10.1097/mcc.0000000000000466
Abstract: Purpose of review The aim of this study was to discuss the recent developments in trauma-induced coagulopathy and the evolvement of goal-directed therapy. Recent findings Mortality from major trauma continues to be a worldwide problem,… read more here.
Keywords: directed therapy; trauma; trauma induced; goal directed ... See more keywords
Role of Fibrinogen in Trauma-Induced Coagulopathy.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American College of Surgeons"
DOI: 10.1097/xcs.0000000000000078
Abstract: BACKGROUND Fibrinogen is the first coagulation factor to decrease after massive hemorrhage. European massive transfusion guidelines recommend early repletion of fibrinogen; however, this practice has not been widely adopted in the US. We hypothesize that… read more here.
Keywords: role fibrinogen; trauma induced; induced coagulopathy; fibrinogen ... See more keywords
French lyophilized plasma versus fresh frozen plasma for the initial management of trauma‐induced coagulopathy: a randomized open‐label trial
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Thrombosis and Haemostasis"
DOI: 10.1111/jth.13929
Abstract: Essentials An immediate supply of plasma in case of trauma‐induced coagulopathy is required. The Traucc trial compared French Lyophilised Plasma (FLyP) and Fresh Frozen Plasma (FFP). FLyP achieved higher fibrinogen concentrations compared with FFP. FLyP… read more here.
Keywords: plasma; frozen plasma; fresh frozen; trauma induced ... See more keywords
Response to Letter to the Editor submitted by Dr. Wada and Dr. Yamakawa re: Trauma‐induced coagulopathy: The past, present, and future
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Thrombosis and Haemostasis"
DOI: 10.1111/jth.14581
Abstract: It is with equal appreciation and enthusiasm that we have the opportunity to participate in these valuable scientific discussions with our respected colleagues Dr. Wada and Dr. Yamakawa, as we did with Dr. Gando and… read more here.
Keywords: wada yamakawa; induced coagulopathy; trauma induced; response ... See more keywords
The use of cryopreserved platelets in a trauma‐induced hemorrhage model
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DOI: 10.1111/trf.15937
Abstract: Cryopreserved platelet products can be stored for years and are mainly used in military settings. Following thawing, cryopreserved platelets are activated, resulting in faster clot formation but reduced aggregation in vitro, rendering their efficacy in… read more here.
Keywords: induced hemorrhage; use cryopreserved; platelets trauma; hemorrhage ... See more keywords
Evaluation of trauma‐induced coagulopathy in the fibrinogen in the initial resuscitation of severe trauma trial
Sign Up to like & getrecommendations! Published in 2021 at "Transfusion"
DOI: 10.1111/trf.16488
Abstract: Coagulopathic bleeding is frequently present after major trauma. However, trauma‐induced coagulopathy (TIC) remains incompletely understood. This laboratory analysis of blood samples derived from our completed trial on fibrinogen in the initial resuscitation of severe trauma… read more here.
Keywords: fibrinogen initial; initial resuscitation; trauma; trauma induced ... See more keywords
Enabling the assessment of trauma-induced hemorrhage via smart wearable systems
Sign Up to like & getrecommendations! Published in 2020 at "Science Advances"
DOI: 10.1126/sciadv.abb1708
Abstract: Assessing the mechanical function of the heart using wearable sensors may soon enable robust, data-driven treatment of hemorrhage. As the leading cause of trauma-related mortality, blood loss due to hemorrhage is notoriously difficult to triage… read more here.
Keywords: enabling assessment; wearable systems; hemorrhage; trauma induced ... See more keywords