Evaluation of articular cartilage with quantitative MRI in an equine model of post‐traumatic osteoarthritis
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Orthopaedic Research"
DOI: 10.1002/jor.24780
Abstract: Chondral lesions lead to degenerative changes in the surrounding cartilage tissue, increasing the risk of developing post‐traumatic osteoarthritis (PTOA). This study aimed to investigate the feasibility of quantitative magnetic resonance imaging (qMRI) for evaluation of… read more here.
Keywords: post traumatic; traumatic osteoarthritis; articular cartilage; evaluation articular ... See more keywords
Systemic Inhibition or Global Deletion of CaMKK2 Protects Against Post-Traumatic Osteoarthritis.
Sign Up to like & getrecommendations! Published in 2021 at "Osteoarthritis and cartilage"
DOI: 10.1016/j.joca.2021.09.001
Abstract: OBJECTIVE To investigate the role of Ca2+/calmodulin-dependent protein kinase kinase 2 (CaMKK2) in post-traumatic osteoarthritis (PTOA). METHODS Destabilization of the medial meniscus (DMM) or sham surgeries were performed on 10-week-old male wild-type (WT) and Camkk2-/-… read more here.
Keywords: post traumatic; traumatic osteoarthritis; osteoarthritis; inhibition ... See more keywords
A VCP modulator, KUS121, as a promising therapeutic agent for post-traumatic osteoarthritis
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-77735-2
Abstract: Post-traumatic osteoarthritis (PTOA) is a major cause which hinders patients from the recovery after intra-articular injuries or surgeries. Currently, no effective treatment is available. In this study, we showed that inhibition of the acute stage… read more here.
Keywords: post traumatic; therapeutic agent; traumatic osteoarthritis; ptoa ... See more keywords
Coculture with interleukin-10 overexpressed chondrocytes: a cell therapy model to ameliorate the post-traumatic osteoarthritis development.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of biological regulators and homeostatic agents"
DOI: 10.23812/21-40-a
Abstract: Autologous chondrocyte (CH) transplantation is a novel strategy to treat post-traumatic osteoarthritis (PTOA). In this study, an in vitro coculture model was used to explore the effects of interleukin (IL)-10 overexpressed CHs on degenerated CHs.… read more here.
Keywords: overexpressed chs; interleukin overexpressed; coculture; traumatic osteoarthritis ... See more keywords
Single-cell RNA-Seq reveals changes in immune landscape in post-traumatic osteoarthritis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.938075
Abstract: Osteoarthritis (OA) is the most common joint disease, affecting over 300 million people world-wide. Accumulating evidence attests to the important roles of the immune system in OA pathogenesis. Understanding the role of various immune cells… read more here.
Keywords: cell; osteoarthritis; single cell; cell rna ... See more keywords
Experimental animal models of post-traumatic osteoarthritis of the knee
Sign Up to like & getrecommendations! Published in 2020 at "Orthopedic Reviews"
DOI: 10.4081/or.2020.8448
Abstract: Due to the complex and dynamic nature of osteoarthritis (OA) and post-traumatic osteoarthritis (PTOA), animal models have been used to investigate the progression and pathogenesis of the disease. Researchers have used different experimental models to… read more here.
Keywords: post traumatic; experimental animal; traumatic osteoarthritis; osteoarthritis ... See more keywords