Trazodone and patient outcomes in dementia—Limitations of naturalistic cohort data
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Geriatric Psychiatry"
DOI: 10.1002/gps.5777
Abstract: The unfolded protein response has been increasingly implicated as an important pathological pathway and target for therapeutic intervention in neurodegeneration. The licensed antidepressant trazodone is one drug which has been proposed to act on this… read more here.
Keywords: outcomes dementia; patient outcomes; trazodone patient; patient ... See more keywords
Effect of 3 Single Doses of Trazodone on QTc Interval in Healthy Subjects
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DOI: 10.1002/jcph.1640
Abstract: This study evaluated the effect of 3 doses of a trazodone hydrochloride 6% oral drops solution on the QT interval of healthy volunteers. Subjects were randomly assigned to receive a single dose of trazodone 20… read more here.
Keywords: qtc; doses trazodone; trazodone; effect ... See more keywords
Érythème pigmenté fixe à la trazodone
Sign Up to like & getrecommendations! Published in 2019 at "Annales De Dermatologie Et De Venereologie"
DOI: 10.1016/j.annder.2019.09.180
Abstract: Introduction L’erytheme pigmente fixe (EPF) est une toxidermie de type retardee. Il se manifeste dans les 48 h suivant la reintroduction d’un medicament par l’apparition d’une eruption recurrente, laissant une hyperpigmentation residuelle. Observations Patient de 86 ans,… read more here.
Keywords: fixe; pigmente fixe; trazodone; erytheme pigmente ... See more keywords
0506 Short and Long-Term Effects of Trazodone vs. Cognitive-Behavioral Treatment on EEG Power During NREM Sleep in Chronic Insomnia
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DOI: 10.1093/sleep/zsaa056.503
Abstract: Both trazodone and cognitive-behavioral treatment of insomnia (CBT-I) are widely used to treat patients with chronic insomnia. Animal studies have shown that trazodone increases slow wave sleep (i.e., increased EEG delta power). However, no study… read more here.
Keywords: power nrem; treatment; trazodone; nrem sleep ... See more keywords
A randomized, double-blind study comparing the efficacy and safety of trazodone once-a-day and venlafaxine extended-release for the treatment of patients with major depressive disorder
Sign Up to like & getrecommendations! Published in 2020 at "International Clinical Psychopharmacology"
DOI: 10.1097/yic.0000000000000304
Abstract: Supplemental Digital Content is available in the text. This double-blind, randomized study evaluated the efficacy and safety of trazodone OAD (once-a-day) in comparison with venlafaxine XR (extended-release) in 324 patients (166 trazodone and 158 venlafaxine)… read more here.
Keywords: venlafaxine; double blind; efficacy; treatment ... See more keywords
Estimation of brain receptor occupancy for trazodone immediate release and once a day formulations.
Sign Up to like & getrecommendations! Published in 2022 at "Clinical and translational science"
DOI: 10.1111/cts.13253
Abstract: Trazodone is approved for the treatment of major depressive disorders, marketed as immediate release (IR), prolonged release, and once a day (OAD) formulation. The different formulations allow different administration schedules and may be useful to… read more here.
Keywords: release; formulation; day; trazodone ... See more keywords
PK/PD analysis of trazodone and gabapentin in neuropathic pain rodent models: Translational PK‐PD modeling from nonclinical to clinical development
Sign Up to like & getrecommendations! Published in 2023 at "Clinical and Translational Science"
DOI: 10.1111/cts.13472
Abstract: A pharmacokinetic/pharmacodynamic (PK/PD) model was developed to describe the time course of writhings after intraperitoneal injection of acetic acid in mice. The model was applied to investigate the antinociceptive effect of trazodone and gabapentin alone… read more here.
Keywords: effect; development; trazodone gabapentin; model ... See more keywords
Pharmacokinetic, sedative, and physiological effects of oral compounded formulations of trazodone alone or in combination with gabapentin in male cats.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of veterinary pharmacology and therapeutics"
DOI: 10.1111/jvp.13384
Abstract: Trazodone and gabapentin are common oral sedatives in cats, used alone or combined, but no pharmacokinetic studies exist for trazodone in this species. The objective of this study was to determine the pharmacokinetics of oral… read more here.
Keywords: trazodone alone; combination gabapentin; alone combination; pharmacokinetic sedative ... See more keywords
Suspected hepatotoxicity secondary to trazodone therapy in a dog.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of veterinary emergency and critical care"
DOI: 10.1111/vec.13028
Abstract: OBJECTIVE To describe a case of suspected hepatotoxicity in a dog secondary to administration of trazodone. CASE SUMMARY A 6-year-old, neutered, mixed breed dog was evaluated for a progressive increased liver enzyme activity over a… read more here.
Keywords: trazodone therapy; trazodone; secondary trazodone; hepatotoxicity ... See more keywords
Physiologically Based Dissolution Testing in a Drug Development Process—a Case Study of a Successful Application in a Bioequivalence Study of Trazodone ER Formulations Under Fed Conditions
Sign Up to like & getrecommendations! Published in 2020 at "AAPS PharmSciTech"
DOI: 10.1208/s12249-020-01662-8
Abstract: Development of generic extended-release (ER) formulations is challenging. Especially under fed conditions, the risk of failure in bioequivalence trials is high because of long gastric residence times and susceptibility to food effects. We describe the… read more here.
Keywords: bioequivalence; fed conditions; trazodone; study ... See more keywords
EFFECTS OF A SINGLE ORAL DOSE OF TRAZODONE ON BEHAVIOR AND SERUM CORTISOL LEVELS IN BLUE WILDEBEEST (CONNOCHAETES TAURINUS)
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Zoo and Wildlife Medicine"
DOI: 10.1638/2021-0145
Abstract: Abstract: Trazodone is a dose-dependent serotonin antagonist and agonist used to treat anxiety-related conditions. Trauma has been identified as the leading cause of morbidity and mortality in several nondomestic ruminant species and can be exacerbated… read more here.
Keywords: serum cortisol; cortisol levels; dose trazodone; blue wildebeest ... See more keywords