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   Articles with "trazodone" as a keyword



Trazodone and patient outcomes in dementia—Limitations of naturalistic cohort data

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recommendations! Published in 2022 at "International Journal of Geriatric Psychiatry"

DOI: 10.1002/gps.5777

Abstract: The unfolded protein response has been increasingly implicated as an important pathological pathway and target for therapeutic intervention in neurodegeneration. The licensed antidepressant trazodone is one drug which has been proposed to act on this… read more here.

Keywords: outcomes dementia; patient outcomes; trazodone patient; patient ... See more keywords
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Effect of 3 Single Doses of Trazodone on QTc Interval in Healthy Subjects

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recommendations! Published in 2020 at "Journal of Clinical Pharmacology"

DOI: 10.1002/jcph.1640

Abstract: This study evaluated the effect of 3 doses of a trazodone hydrochloride 6% oral drops solution on the QT interval of healthy volunteers. Subjects were randomly assigned to receive a single dose of trazodone 20… read more here.

Keywords: qtc; doses trazodone; trazodone; effect ... See more keywords

Érythème pigmenté fixe à la trazodone

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recommendations! Published in 2019 at "Annales De Dermatologie Et De Venereologie"

DOI: 10.1016/j.annder.2019.09.180

Abstract: Introduction L’erytheme pigmente fixe (EPF) est une toxidermie de type retardee. Il se manifeste dans les 48 h suivant la reintroduction d’un medicament par l’apparition d’une eruption recurrente, laissant une hyperpigmentation residuelle. Observations Patient de 86 ans,… read more here.

Keywords: fixe; pigmente fixe; trazodone; erytheme pigmente ... See more keywords

A realworld pharmacovigilance study of trazodone based on the FDA adverse event reporting system

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recommendations! Published in 2025 at "Scientific Reports"

DOI: 10.1038/s41598-025-89632-7

Abstract: To explore and analyze the potential adverse event (AE) signals of trazodone, with reference to the safe clinical use of drugs. Based on the FDA Adverse Event Reporting System (FAERS), the AE data of trazodone… read more here.

Keywords: event reporting; trazodone; fda adverse; based fda ... See more keywords

Trazodone in neurology, a new life for an old molecule - an updated, comprehensive, systematic review of clinical trials.

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recommendations! Published in 2025 at "International journal of psychiatry in clinical practice"

DOI: 10.1080/13651501.2025.2572291

Abstract: INTRODUCTION The triazolopyridine derivative trazodone is approved for the treatment of major depressive disorder (MDD) in adults; according to the available literature, this molecule, through a specific dose-dependent profile of action, was found to be… read more here.

Keywords: trazodone; molecule; systematic review; neurology ... See more keywords

Rethinking the role of trazodone in the different depressive dimensions

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recommendations! Published in 2024 at "Expert Review of Neurotherapeutics"

DOI: 10.1080/14737175.2024.2363843

Abstract: ABSTRACT Introduction The efficacy of trazodone for several psychopathologic dimensions of depression has been shown in the literature. Trazodone has been widely used in some clinical contexts (e.g. for insomnia and depression in the elderly).… read more here.

Keywords: trazodone different; trazodone; depressive disorder; major depressive ... See more keywords

LC-MS/MS determination of trazodone in human plasma and its pharmacokinetic study in healthy Chinese.

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recommendations! Published in 2025 at "Bioanalysis"

DOI: 10.1080/17576180.2025.2506349

Abstract: AIMS This study aimed to establish a robust LC-MS/MS method for quantifying trazodone in human plasma and investigate its pharmacokinetic profile in healthy Chinese subjects under fasting and fed conditions. MATERIALS & METHODS A validated… read more here.

Keywords: human plasma; trazodone; method; healthy chinese ... See more keywords
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0506 Short and Long-Term Effects of Trazodone vs. Cognitive-Behavioral Treatment on EEG Power During NREM Sleep in Chronic Insomnia

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recommendations! Published in 2020 at "Sleep"

DOI: 10.1093/sleep/zsaa056.503

Abstract: Both trazodone and cognitive-behavioral treatment of insomnia (CBT-I) are widely used to treat patients with chronic insomnia. Animal studies have shown that trazodone increases slow wave sleep (i.e., increased EEG delta power). However, no study… read more here.

Keywords: power nrem; treatment; trazodone; nrem sleep ... See more keywords

A randomized, double-blind study comparing the efficacy and safety of trazodone once-a-day and venlafaxine extended-release for the treatment of patients with major depressive disorder

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recommendations! Published in 2020 at "International Clinical Psychopharmacology"

DOI: 10.1097/yic.0000000000000304

Abstract: Supplemental Digital Content is available in the text. This double-blind, randomized study evaluated the efficacy and safety of trazodone OAD (once-a-day) in comparison with venlafaxine XR (extended-release) in 324 patients (166 trazodone and 158 venlafaxine)… read more here.

Keywords: venlafaxine; double blind; efficacy; treatment ... See more keywords

Intravenous trazodone for the treatment of psychomotor agitation and associated symptoms in major depressive disorder patients experiencing a depressive episode with mixed features.

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recommendations! Published in 2025 at "International clinical psychopharmacology"

DOI: 10.1097/yic.0000000000000580

Abstract: Psychomotor agitation is a challenging symptom of major depressive disorder with mixed features (MDD-MF), often worsening outcomes and complicating treatment. This retrospective study assessed the efficacy and tolerability of intravenous trazodone in 97 hospitalized patients… read more here.

Keywords: treatment; trazodone; psychomotor agitation; major depressive ... See more keywords

Estimation of brain receptor occupancy for trazodone immediate release and once a day formulations.

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recommendations! Published in 2022 at "Clinical and translational science"

DOI: 10.1111/cts.13253

Abstract: Trazodone is approved for the treatment of major depressive disorders, marketed as immediate release (IR), prolonged release, and once a day (OAD) formulation. The different formulations allow different administration schedules and may be useful to… read more here.

Keywords: release; formulation; day; trazodone ... See more keywords