Development of HPLC method coupled with fluorescence detection for simultaneous determination of donepezil HCl and trazodone HCl in spiked human plasma and tablets dosage forms.
Sign Up to like & getrecommendations! Published in 2019 at "Annales pharmaceutiques francaises"
DOI: 10.1016/j.pharma.2019.02.003
Abstract: OBJECTIVES Elderly people with dementia are commonly suffered from sleep disorders. So, the use of Donepezil hydrochloride as anti-Alzheimer drug and Trazodone hydrochloride as antidepressants with hypnotic action is very important in these cases. This… read more here.
Keywords: donepezil hydrochloride; hydrochloride; trazodone hydrochloride; human plasma ... See more keywords
Influence of Genetic Polymorphisms on the Pharmacokinetics of Trazodone Hydrochloride: a Scoping Review and Future Perspective.
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DOI: 10.1097/ftd.0000000000001049
Abstract: PURPOSE Trazodone hydrochloride is an antidepressant used in clinical practice. As a substrate of cytochrome P450 enzymes that is vulnerable to P-glycoprotein transport, several factors can alter its plasma concentration, and hence, dose adjustment may… read more here.
Keywords: trazodone hydrochloride; genetic polymorphisms; scoping review; pharmacokinetics trazodone ... See more keywords
Design and Development of Gastro-retentive Drug Delivery System for Trazodone Hydrochloride: a Promising Alternative to Innovator’s Controlled-Release Tablet
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DOI: 10.1208/s12249-022-02404-8
Abstract: Trazodone hydrochloride (TZN) is a serotonin reuptake inhibitor that treats a major depressive disorder. It exhibits a short plasma half-life of 4.1 h and shows pH-dependent solubility. Above its pKa (6.74), solubility of TZN is… read more here.
Keywords: formulation; trazodone hydrochloride; gastro retentive; tablet ... See more keywords
Attempting to Increase the Effectiveness of the Antidepressant Trazodone Hydrochloride Drug Using π-Acceptors
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DOI: 10.3390/ijerph191811281
Abstract: Major depressive disorder is a prevalent mood illness that is mildly heritable. Cases with the highest familial risk had recurrence and onset at a young age. Trazodone hydrochloride is an antidepressant medicine that affects the… read more here.
Keywords: transfer complexes; trazodone hydrochloride; tzd; attempting increase ... See more keywords
Comparison of the efficacy of Trazodone hydrochloride tablets alone and in combination with press-needles in the treatment of post-stroke depression.
Sign Up to like & getrecommendations! Published in 2023 at "JPMA. The Journal of the Pakistan Medical Association"
DOI: 10.47391/jpma.6487
Abstract: The purpose of this study was to compare the efficacy of Trazodone hydrochloride tablets alone and in combination with press-needles in the treatment of post-stroke depression. One hundred and four post-stroke depression patients, admitted to… read more here.
Keywords: trazodone hydrochloride; depression; hydrochloride tablets; group ... See more keywords