Discovery of a Novel Small-Molecule Inhibitor Disrupting TRBP-Dicer Interaction against Hepatocellular Carcinoma via the Modulation of microRNA Biogenesis.
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DOI: 10.1021/acs.jmedchem.2c00189
Abstract: MicroRNAs (miRNAs) are key players in human hepatocellular carcinoma (HCC) tumorigenesis. Therefore, small molecules targeting components of miRNA biogenesis may provide new therapeutic means for HCC treatment. By a high-throughput screening and structural simplification, we… read more here.
Keywords: trbp dicer; dicer; hepatocellular carcinoma; small molecule ... See more keywords